Results 41 to 50 of about 1,421,598 (316)
Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. [PDF]
, 2019 HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions.
Fernandes, Jason D +4 more
core +3 more sources
Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila [PDF]
, 1995 The bithorax complex (BX-C) of Drosophila, one of two complexes that act as master regulators of the body plan of the fly, has now been entirely sequenced and comprises approximate to 315,000 bp, only 1.4% of which codes for protein.
Celniker, Susan E. +3 more
core +1 more source
Regulatory Signals in Genomic Sequences [PDF]
, 2007 Gene expression is a complex multiple-step process involving multiple levels of regulation, from transcription, nuclear processing, export, posttranscriptional modifications, translation, to degradation. Over evolutionary timescales, many of the interactions determining the fate of a gene have left traces in the genomic DNA.
Peter F. Stadler +2 more
openaire +2 more sources
Analysis of regulatory sequences in exosomal DNA of NANOGP8
PLOS ONE, 2023 Exosomes participate in intercellular communication by transporting functionally active molecules. Such cargo from the original cells comprising proteins, micro-RNA, mRNA, single-stranded (ssDNA) and double-stranded DNA (dsDNA) molecules pleiotropically transforms the target cells.
Manjusha Vaidya +3 more
openaire +3 more sources
Identification of cis-regulatory sequence variations in individual genome sequences [PDF]
Genome Medicine, 2011 Functional contributions of cis-regulatory sequence variations to human genetic disease are numerous. For instance, disrupting variations in a HNF4A transcription factor binding site upstream of the Factor IX gene contributes causally to hemophilia B Leyden.
Wyeth W. Wasserman +2 more
openaire +3 more sources
PLoS ONE, 2020 With advances in sequencing technology, a vast amount of genomic sequence information has become available. However, annotating biological functions particularly of non-protein-coding regions in genome sequences without experiments is still a challenging
Koh Onimaru +2 more
doaj +1 more source
Identification of the regulatory logic controlling Salmonella pathoadaptation by the SsrA-SsrB two-component system. [PDF]
PLoS Genetics, 2010 Sequence data from the past decade has laid bare the significance of horizontal gene transfer in creating genetic diversity in the bacterial world. Regulatory evolution, in which non-coding DNA is mutated to create new regulatory nodes, also contributes ...
Ana M Tomljenovic-Berube +4 more
doaj +1 more source
Frontiers in Plant Science, 2023 Plants have evolved various mechanisms to adapt to adverse environmental stresses, such as the modulation of gene expression. Expression of stress-responsive genes is controlled by specific regulators, including transcription factors (TFs), that bind to ...
Dajo Smet +6 more
doaj +1 more source
Interfering contexts of regulatory sequence elements [PDF]
Bioinformatics, 1996 Although one would normally expect a given regulatory element to perform best when it fully matches its consensus sequence, this is generally far from being the case. Usually, almost none of the actual sites fits the consensus exactly, and some of those that do fit do not perform well.
openaire +3 more sources
Genomic regulatory sequences in the pathogenesis of bipolar disorder
Frontiers in Psychiatry, 2023 The lifetime prevalence of bipolar disorder is estimated to be about 2%. Epigenetics defines regulatory mechanisms that determine relatively stable patterns of gene expression by controlling all key steps, from DNA to messenger RNA to protein. This Mini Review highlights recent discoveries of modified epigenetic control resulting from genetic variants ...
Anastasia Levchenko +2 more
openaire +3 more sources