Results 61 to 70 of about 1,421,598 (316)
DanQ: a hybrid convolutional and recurrent deep neural network for quantifying the function of DNA sequences. [PDF]
, 2016 Modeling the properties and functions of DNA sequences is an important, but challenging task in the broad field of genomics. This task is particularly difficult for non-coding DNA, the vast majority of which is still poorly understood in terms of ...
Quang, Daniel, Xie, Xiaohui
core +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
CastNet: a systems-level sequence evolution simulator
BMC Bioinformatics, 2023 Background Simulating DNA evolution has been done through coevolution-agnostic probabilistic frameworks for the past 3 decades. The most common implementation is by using the converse of the probabilistic approach used to infer phylogenies which, in the ...
Carlos J. Rivera-Rivera, Djordje Grbic
doaj +1 more source
Learning the Regulatory Code of Gene Expression
Frontiers in Molecular Biosciences, 2021 Data-driven machine learning is the method of choice for predicting molecular phenotypes from nucleotide sequence, modeling gene expression events including protein-DNA binding, chromatin states as well as mRNA and protein levels.
Jan Zrimec +6 more
doaj +1 more source
PseudoFuN: Deriving functional potentials of pseudogenes from integrative relationships with genes and microRNAs across 32 cancers [PDF]
, 2019 BACKGROUND: Long thought "relics" of evolution, not until recently have pseudogenes been of medical interest regarding regulation in cancer. Often, these regulatory roles are a direct by-product of their close sequence homology to protein-coding genes.
Campbell, Moray J. +7 more
core +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
A map of the cis-regulatory sequences in the mouse genome [PDF]
Nature, 2012 The laboratory mouse is the most widely used mammalian model organism in biomedical research. The 2.6 × 10(9) bases of the mouse genome possess a high degree of conservation with the human genome, so a thorough annotation of the mouse genome will be of significant value to understanding the function of the human genome.
David F. McCleary +12 more
openaire +5 more sources
Nature CommunicationsRegulatory sequences encode crucial gene expression signals, yet the sequence characteristics that determine their functionality across species remain obscure.
Pengcheng Zhang +4 more
doaj +1 more source
Genetics and regulatory impact of alternative polyadenylation in human B-lymphoblastoid cells.
PLoS Genetics, 2012 Gene expression varies widely between individuals of a population, and regulatory change can underlie phenotypes of evolutionary and biomedical relevance.
Oh Kyu Yoon +3 more
doaj +1 more source
The role of Gdf5 regulatory regions in development of hip morphology. [PDF]
PLoS ONE, 2018 Given GDF5 involvement in hip development, and osteoarthritis (OA) and developmental hip dysplasia (DDH) risk, here we sought to assess the role(s) of GDF5 and its regulatory sequence on the development of hip morphology linked to injury risk.
Ata M Kiapour +3 more
doaj +1 more source