Results 111 to 120 of about 2,996,073 (354)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Developing in vitro expanded CD45RA⁺regulatory T cells as an adoptive cell therapy for Crohn's disease [PDF]

, 2015
James B. Canavan, Cristiano Scottà, Anna Vossenkämper, Rimma Goldberg, Matthew J. Elder, Irit Shoval, Ellen Marks, Émilie Stolarczyk, Jonathan W. Lo, Nick Powell, Henrieta Fazekasova, Peter M. Irving, Jeremy Sanderson, Jane K. Howard, Simcha Yagel, Behdad Afzali, Thomas T. MacDonald, María P. Hernández-Fuentes, Nahum Y. Shpigel, Giovanna Lombardi, Graham M. Lord   +20 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

FOXP3 is a direct target of miR15a/16 in umbilical cord blood regulatory T cells [PDF]

, 2014
X Liu, Simon N. Robinson, Tetsuro Setoyama, Samuel Tung, Lucilla D’Abundo, Maitri Shah, Hui Yang, Eric Yvon, Nina Shah, Hui Yang, M. Konopleva, Guillermo Garcia‐Manero, Ian McNiece, Katayoun Rezvani, George A. Călin, E.J. Shpall, Simrit Parmar   +16 more
openalex   +1 more source

Regulatory T Cells [PDF]

Cell, 2000
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Neither T-helper type 2 nor Foxp3+regulatory T cells are necessary for therapeutic benefit of atorvastatin in treatment of central nervous system autoimmunity [PDF]

, 2014
Martin S. Weber, Thomas Prod’homme, Sawsan Youssef, Shannon E. Dunn, Lawrence Steinman, Scott S. Zamvil   +5 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

Immunity, 2005
J. Fontenot, J. P. Rasmussen, L. Williams, James L. Dooley, A. Farr, A. Rudensky   +5 more
semanticscholar   +1 more source

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elements [PDF]

, 2023
Andrew D. Wells, Matthew C. Pahl, Prabhat Sharma, Rajan M. Thomas, Zachary Thompson, Zachary Mount, James A. Pippin, Peter A. Morawski, Daniel Campbell, Struan F.A. Grant, Chun Su   +10 more
openalex   +1 more source