Results 251 to 260 of about 2,009,353 (358)

Reactivity and Regulatory Properties of Human Anti-Idiotypic Antibodies Induced by T Cell Vaccination [PDF]

, 2000
Jian Hong, Ying C. Q. Zang, Maria V. Tejada‐Simon, Sufang Li, Víctor M. Rivera, James Killian, Jingwu Z. Zhang   +6 more
openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Regulatory T cell therapy in autoimmune liver disease and transplantation. [PDF]

JHEP Rep
Fleming M, Sanchez-Fueyo A, Safinia N.
europepmc   +1 more source

CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells [PDF]

, 2000
Lukas Cederbom, Håkan Hall, Fredrik Ivars   +2 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

The Streptomyces Metabolite Thiostrepton Inhibits Regulatory T Cell Differentiation and Function to Boost Antitumor Immune Responses. [PDF]

Eur J Immunol
Silva L, Almeida L, Al-Naimi F, Nascimento DC, Lopez Krol A, Damasceno LEA, Echchannaoui H, Alves-Filho JC, Berod L, Sparwasser T.   +9 more
europepmc   +1 more source

Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment [PDF]

, 2000
Oliver Annacker, Odile Burlen‐Defranoux, Ricardo Pimenta‐Araujo, Ana Cumano, António Bandeira   +4 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model. [PDF]

J Neuroinflammation
Kong WX, Zhang ZL, Li J, Zhu S, Li C, Dong XL, Gan TT, Hu D, Liang FC, Xu PY, Guo WY.   +10 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source