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Targeting regulatory T cells

Targeted Oncology, 2012
Cancers express tumor-associated antigens that should elicit immune response to antagonize the tumor growth, but spontaneous immune rejection of established cancer is rare, suggesting an immunosuppressive environment hindering host antitumor immunity.
Ménétrier-Caux, Christine   +5 more
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Brain regulatory T cells

Nature Reviews Immunology, 2023
The brain, long thought to be isolated from the peripheral immune system, is increasingly recognized to be integrated into a systemic immunological network. These conduits of immune-brain interaction and immunosurveillance processes necessitate the presence of complementary immunoregulatory mechanisms, of which brain regulatory T cells (Treg cells) are
Adrian Liston   +3 more
openaire   +4 more sources

[Regulatory T cells].

Annales de dermatologie et de venereologie, 2007
International ...
Aubin, François, Saas, Philippe
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An overview of regulatory T cells

Microbes and Infection, 2001
The induction of tolerance is essential for the maintenance of immune homeostasis and for the prevention of autoimmune diseases. To induce tolerance the immune system uses several mechanisms, including the deletion of autoreactive T cells, the induction of anergy and active suppression of autoimmune responses.
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Regulatory T Cells in Cancer

2010
At the present time, regulatory T cells (Tregs) are an integral part of immunology but the route from discovery of "suppressive" lymphocytes in the 1980s to the current established concept of Tregs almost 20 years later has been a rollercoaster ride.
Dimitrios, Mougiakakos   +4 more
openaire   +2 more sources

CD147 in regulatory T cells

Cellular Immunology, 2013
CD147 or EMMPRIN belongs to the immunoglobulin superfamily of membrane receptors and is expressed in epithelial cells, cancer cells and T cells of the immune system. In T cells CD147 functions as a receptor for soluble cyclophilins and is involved in chemotaxis.
Johannes, Landskron, Kjetil, Taskén
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Regulatory T cells and asthma

Clinical & Experimental Allergy, 2009
AbstractAirway inflammation in asthma is characterized by activation of T helper type‐2 (Th2) T cells, IgE production and eosinophilia. In many cases, this process is related to an inappropriate T cell response to environmental allergens, and other T cell‐dependent pathways may also be involved (such as Th17).
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T regulatory cells and allergy

Microbes and Infection, 2005
Anergy, tolerance and active suppression may not be independent events, but rather involve similar mechanisms and cell types in immune regulation. Induction of allergen-specific T(Reg) cells seems essential for maintaining a healthy immune response towards allergens. By utilizing multiple secreted cytokines and surface molecules, antigen-specific T(Reg)
Taylor A, Verhagen J, Akdis CA, Akdis M
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Regulatory T cells in Arthritis

2015
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases and is characterized by inflammation and subsequent bone destruction in multiple joints. In mice, depletion of regulatory T (Treg) cells results in the onset of a variety of autoimmune diseases including arthritis, while replenishment of Treg cells alleviates arthritic symptoms ...
Noriko, Komatsu, Hiroshi, Takayanagi
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Regulatory T cells in cancer

Blood, 2006
AbstractIncreasing evidence supports the existence of elevated numbers of regulatory T cells (Treg cells) in solid tumors and hematologic malignancies. Whereas the biology of CD4+CD25+FOXP3+ Treg cells in murine models seems to be rather straightforward, studies in human diseases are more difficult to interpret due to expression of CD25 on activated ...
Marc, Beyer, Joachim L, Schultze
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