Results 211 to 220 of about 1,257,811 (269)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

miRNA/mRNA analysis of increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiation. [PDF]

Front Immunol
Darville T, Sun X, Zhang Y, O'Connell CM, Mokashi NV, Tang W, Bhardwaj A, Duncan B, Andrews CW, Wiesenfeld HC, Zheng X.   +10 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation. [PDF]

iScience
Mitchell-Flack M, Higgins M, Zheng Y, Tam A, Goldschmidt H, Nishio H, Liu B, Cherry CM, Patatanian M, Blosser R, Mun SS, Suru A, Huganir R, Yu H, Pardoll D.   +14 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Inhibition of estrogen receptor alpha stabilizes regulatory T cell function in autoimmune hepatitis. [PDF]

JHEP Rep
Zhang L, Gromova B, Nguyen DH, Cagle C, Gomes GS, Li W, Gao L, Zhang W, Graham JJ, Wang N, Kalbasi A, Csizmadia E, Wei A, Cassavaugh J, Bonder A, Patwardhan V, Jiang S, Kota SK, Longhi MS.   +18 more
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Longitudinal immune profiling uncovers regulatory T cell signatures associated with the progression of COVID-19. [PDF]

Front Immunol
Kossack C, Bravo F, Fuentes-Villalobos F, Quevedo C, Medina MA, Riquelme R, Rioseco ML, Calvo M, Pino-Lagos K, Aguilera F, Barría MI, Garrido JL.   +11 more
europepmc   +1 more source

Modulation of Gut Microbiota Through Dietary Fibers to Enhance Regulatory T Cell-Based Immunotherapy in GVHD Following Hematopoietic Stem Cell Transplantation. [PDF]

Nutrients
Asayesh M, Nazarzadeh A, Jamshidi S, Keramat S, Ryszkiel I, Stanek A.   +5 more
europepmc   +1 more source

The Potential of β-Synuclein-Specific Regulatory T Cell Therapy as a Treatment for Progressive Multiple Sclerosis. [PDF]

Int J Mol Sci
Osmond GE, John NA, Ting YT, Ooi JD.
europepmc   +1 more source