Results 211 to 220 of about 1,279,789 (265)

Inborn errors of regulatory T-cell differentiation and function. [PDF]

J Allergy Clin Immunol
Oktelik FB, Luo Y, Benamar M, Chatila TA.   +3 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Prednisolone modulates CD8⁺ and regulatory T-cell activity to dampen response to immune checkpoint inhibitor therapy in melanoma. [PDF]

Oncoimmunology
Brown JR, Pedersen B, Long GV, Maher NG, Lim SY, Rizos H, Shklovskaya E.   +6 more
europepmc   +1 more source

Regulatory T cell therapy in autoimmune and immune-mediated diseases: from basic research to clinical practice and future perspectives. [PDF]

Front Immunol
Duan S, Zhang J, Chen Z, He Y, Zhang Y, Guo H.   +5 more
europepmc   +1 more source

Regulatory T cell memory: implications for malaria. [PDF]

J Immunol
Charles-Chess NAE, Kurup SP.
europepmc   +1 more source

Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression. [PDF]

Cancer Cell
Bui TM, Jimenez ER, Li Z, Foidart P, Puleo J, Yan P, Jhaveri A, Yang L, Nishida J, Seehawer M, Cai X, Parker KA, Qin X, Sumer OE, Huang XY, Patel A, Dillon D, McDonnell CH, Rowberry R, Jhajj S, Baker C, Brown DD, Strand SH, Marks JR, Colditz GA, Park SY, Lee AV, Angelo M, McAuliffe PF, Bobolis K, West R, Dranoff G, Hwang ES, Cristea S, Polyak K.   +34 more
europepmc   +1 more source

Regulatory T Cell-Based Adoptive Cell Therapy in Autoimmunity. [PDF]

Int J Mol Sci
Gozálvez E, Lario A, Muñoz-Sánchez G, Lozano F.   +3 more
europepmc   +1 more source

Regulatory T-cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth. [PDF]

Cancer Immunol Res
Santiago-Carvalho I, Francisco R, Macedo BG, Salgado CL, Stoll CR, Shao S, Beniwal A, Kwok T, Banuelos A, Cione MP, White E, Johnston TM, Leff CL, Silva Junior I, Carvalho de Souza F, Thant W, Pandya P, D'Império Lima MR, Fernandez-Bussy S, Abia-Trujillo D, Vu LH, Tran NL, Husta BC, Copland JA, Gounari F, Justilien V, Lancaster JN, Borges da Silva H.   +27 more
europepmc   +1 more source

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Regulatory T Cell Development

Annual Review of Immunology, 2020
Foxp3-expressing CD4+regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets ...
David Klawon, Peter Savage, Christine H Miller   +2 more
exaly   +3 more sources

Thymic regulatory T cells

Autoimmunity Reviews, 2005
Several types of T regulatory (Treg) cells have been described in both mice and humans, including natural or professional (CD4+CD25+ T cells) and adaptive (Th3 and Tr1 cells) Treg cells. The former develops in the thymus and results in an endogeneous long-lived population of self-antigen-specific T cells in the periphery poised to prevent potentially ...
MAGGI, ENRICO, COSMI, LORENZO, LIOTTA, FRANCESCO, ROMAGNANI, PAOLA, ROMAGNANI, SERGIO, ANNUNZIATO, FRANCESCO   +5 more
openaire   +3 more sources