Results 301 to 310 of about 2,009,353 (358)

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, EarlyView.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

Regulatory T Cell Dysfunction in Autoimmune Diseases. [PDF]

Int J Mol Sci
Honing DY, Luiten RM, Matos TR.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment. [PDF]

Chin Med J (Engl)
Huang T, Li F, Wang Y, Gu J, Lu L.
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Quantitative Approach to Explore Regulatory T Cell Activity in Immuno-Oncology. [PDF]

Pharmaceutics
Serrano A, Zalba S, Lasarte JJ, Troconiz IF, Riva N, Garrido MJ.   +5 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Long noncoding RNA BCYRN1 promotes cardioprotection by enhancing human and murine regulatory T cell dynamics. [PDF]

J Clin Invest
Liao K, Yu J, Akhmerov A, Mohammadigoldar Z, Li L, Liu W, Anders N, Ibrahim AG, Marbán E.   +8 more
europepmc   +1 more source

Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes. [PDF]

J Neuroinflammation
Llorián-Salvador M, Pérez-Martínez D, Tang M, Duarri A, García-Ramirez M, Deàs-Just A, Álvarez-Guaita A, Ramos-Pérez L, Bogdanov P, Gomez-Sanchez JA, Stitt AW, Hernández C, de la Fuente AG, Simó R.   +13 more
europepmc   +1 more source

ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development. [PDF]

Redox Biol
Satooka H, Nakamura Y, Hirata T.
europepmc   +1 more source