Results 71 to 80 of about 2,996,073 (354)

HIF-2α is indispensable for regulatory T cell function

Nature Communications, 2020
HIF-1α is known to repress regulatory T (Treg) cell function, but less is known about the effect of HIF-2α on these cells. Here, the authors use three different mouse models of inflammatory diseases to show that HIF-2α limits HIF-1α expression and is ...
Tzu-Sheng Hsu, Yen-Lin Lin, Yu-An Wang, Shu-Ting Mo, Po-Yu Chi, Alan Chuan-Ying Lai, Hsuan-Yin Pan, Ya-Jen Chang, Ming-Zong Lai   +8 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

Frontiers in Immunology, 2018
T-cell activation is characteristic during the development of atherosclerosis. While overall T-cell responses have been implicated in disease acceleration, regulatory T cells (Tregs) exhibit atheroprotective effects.
Maria J. Forteza, Konstantinos A. Polyzos, Roland Baumgartner, Bianca E. Suur, Bianca E. Suur, Marion Mussbacher, Daniel K. Johansson, Andreas Hermansson, Göran K. Hansson, Daniel F. J. Ketelhuth   +9 more
doaj   +1 more source

Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

Nature Communications, 2018
Defining the suppressive mechanisms used by regulatory T (Treg) cells is critical for the development of effective strategies for treating tumors and chronic infections.
Xia Liu, W. Mo, Jian Ye, Lingyun Li, Yanping Zhang, E. Hsueh, D. Hoft, Guangyong Peng   +7 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Circulating level of regulatory T cells in rheumatic heart disease: An observational study

Indian Heart Journal, 2016
Background: The regulatory T cell (Treg) is essential for prevention of autoimmunity. In a preliminary study, we showed significant deficiency of Tregs (CD4CD25 T cells) in rheumatic heart disease (RHD) patients (an autoimmune disease), but the markers ...
Saibal Mukhopadhyay, Saurabh Varma, H.N. Mohan Kumar, Jamal Yusaf, Mayank Goyal, Vimal Mehta, Sanjay Tyagi   +6 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Infective Larvae of Brugia malayi Induce Polarization of Host Macrophages that Helps in Immune Evasion

Frontiers in Immunology, 2018
Filarial parasites suppress, divert, or polarize the host immune response to aid their survival. However, mechanisms that govern the polarization of host MΦs during early filarial infection are not completely understood. In this study, we infected BALB/c
Aditi Sharma, Aditi Sharma, Pankaj Sharma, Laxmi Ganga, Neha Satoeya, Shikha Mishra, Achchhe Lal Vishwakarma, Mrigank Srivastava, Mrigank Srivastava   +8 more
doaj   +1 more source

Regulatory T Cells in Transplantation

Transplantation Proceedings, 2011
T Regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance to self and alloantigens. Recent findings in experimental transplant models have demonstrated that Treg can control acute and delayed allograft rejection.
openaire   +6 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source