Results 231 to 240 of about 1,141,931 (248)

Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera. [PDF]

Mol Biomed
Zeng Y, Chen X, Huang W, Chan CH, Chen Z, Lyu M, Liu Y, Liu M, Lyu A, Mauro C, Yu Y, Cheung KC.   +11 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Cyanidin-3-O-glucoside-mediated reduction of regulatory T cells: a therapeutic strategy for multiple myeloma. [PDF]

BMC Immunol
Chen H, Fang K, Zong J, Chang X.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Heteromeric Dopamine Receptor D2:D3 Controls the Gut Recruitment and Suppressive Activity of Regulatory T-Cells. [PDF]

Int J Mol Sci
Mora J, Raïch I, Ugalde V, Navarro G, Prado C, Vidal PM, Leal P, Espinoza A, Liu M, Weersma R, Gacesa R, Hermoso MA, Franco R, Pacheco R.   +13 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD-1 Immunotherapy. [PDF]

Cancer Res
Arnouk SM, Kancheva D, Van Damme H, Courtoy GE, Mora Barthelmess R, Van Craenenbroeck J, Lebegge E, Elkrim Y, Assaf N, Heremans Y, Murgaski A, De Groof TWM, Clappaert E, Debraekeleer A, Brughmans J, Blancke G, Kiss M, Forsyth R, Waelput W, Boon L, Devoogdt N, Stortelers C, van Boxel N, Dombrecht B, Vereecke L, Vincke C, Raes G, Laoui D, Van Ginderachter JA.   +28 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Generating tolerance through in situ recruitment of regulatory T cells for allogeneic cell transplantation in a bioengineered lymphoid platform. [PDF]

Mater Today Bio
Kota N, Settis D, Concato M, Risso N, Vander Pol R, Lewis C, Liu Y, Arefeayne Y, Banche-Niclot F, Segatori L, Taraballi F, Mai J, Grattoni A, Chua CYX.   +13 more
europepmc   +1 more source

VISTA⁺ follicular regulatory T cells modulate the function of effector immune cells: implications for ovarian cancer immune escape. [PDF]

Front Immunol
Ma Y, Xu Y, Yu C, Wu H, Li L.
europepmc   +1 more source