Results 211 to 220 of about 1,927,651 (292)

Targeting intratumoral regulatory T cells by CD137 aptamer-shRNA chimeras. [PDF]

Immunother Adv
Lee KY, Mei Y, Liu H, Schwarz H.
europepmc   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

From pathogenesis to therapy: the emerging role of regulatory T cells in amyotrophic lateral sclerosis. [PDF]

J Neuroinflammation
Zhang N, Su WM, Chen T, Zhang Q, Cao B, Wang Y, Chen YP.   +6 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease. [PDF]

Front Immunol
Getachew F, Hu J, Benamar M.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Functional Impairment of Activated Regulatory T Cells as a Central Immunological Defect in Endometriosis. [PDF]

Reprod Med Biol
Tanaka Y, Maeda E, Okimura H, Fujii M, Tarumi Y, Hamaguchi M, Michiaki F, Khan KN, Kitawaki J, Mori T.   +9 more
europepmc   +1 more source

Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

CD318 expression defines a novel subset of human CD8⁺ regulatory T cells. [PDF]

Sci Adv
Do JS, Chen WK, Hung YW, Arribas-Layton D, Lu C, Gu A, Montero E, Carmo AM, Reijonen H.   +8 more
europepmc   +1 more source