Results 211 to 220 of about 14,721,754 (256)

Regulatory T-Cells and Autoimmunity

Journal of Surgical Research, 2006
Approximately 20% of the population is affected by autoimmune or inflammatory diseases mediated by an abnormal immune response. A characteristic feature of autoimmune disease is the selective targeting of a single cell type, organ or tissue by certain populations of autoreactive T-cells.
Niamh, Ni Choileain, H P, Redmond
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T regulatory cells turn on T regulatory cells

Blood, 2009
In this issue of Blood , Miao and colleagues demonstrate that Tregs from a FoxP3 transgenic mouse injected with a normally immunogenic FVIII plasmid not only suppress the response to FVIII but also may “turn on” host Tregs upon adoptive transfer.
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T follicular regulatory cells

Immunological Reviews, 2016
SummaryPathogen exposure elicits production of high‐affinity antibodies stimulated by T follicular helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and stimulatory cytokines to B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiation within the germinal center.
Peter T, Sage, Arlene H, Sharpe
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Regulatory T cells in the periphery

Immunological Reviews, 2006
Summary:  Recognition of a systemic antigen by CD4+ T cells in a lymphopenic host leads to the sequential generation of pathogenic effector cells and protective CD25+ forkhead box protein (Foxp3+) regulatory T cells (Tregs) in the periphery. Such an experimental model is potentially valuable for defining the stimuli that determine the balance of ...
Jens, Lohr, Birgit, Knoechel, Abul K, Abbas   +2 more
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Regulatory T Cell Development

Annual Review of Immunology, 2020
Foxp3-expressing CD4+regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets ...
Peter A, Savage, David E J, Klawon, Christine H, Miller   +2 more
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The life of regulatory T cells

Annals of the New York Academy of Sciences, 2013
Foxp3+ regulatory T (Treg) cells are essential for maintaining self‐tolerance and preventing autoimmune reactions. Treg cells arise as a consequence of self‐antigen recognition during the maturation of cells in the thymus, and also following self‐antigen recognition in the periphery.
Iris K, Gratz, Michael D, Rosenblum, Abul K, Abbas   +2 more
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Intestinal Regulatory T Cells

2021
Mucosal surfaces are distinctive sites exposed to environmental, dietary, and microbial antigens. Particularly in the gut, the host continuously actively adapts via complex interactions between the microbiota and dietary compounds and immune and other tissue cells.
Vanessa R, Figliuolo da Paz, Deepa R, Jamwal, Pawel R, Kiela   +2 more
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[Regulatory T cells].

Annales de dermatologie et de venereologie, 2007
International ...
Aubin, François, Saas, Philippe
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T regulatory cells and allergy

Microbes and Infection, 2005
Anergy, tolerance and active suppression may not be independent events, but rather involve similar mechanisms and cell types in immune regulation. Induction of allergen-specific T(Reg) cells seems essential for maintaining a healthy immune response towards allergens. By utilizing multiple secreted cytokines and surface molecules, antigen-specific T(Reg)
Taylor A, Verhagen J, Akdis CA, Akdis M
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An overview of regulatory T cells

Microbes and Infection, 2001
The induction of tolerance is essential for the maintenance of immune homeostasis and for the prevention of autoimmune diseases. To induce tolerance the immune system uses several mechanisms, including the deletion of autoreactive T cells, the induction of anergy and active suppression of autoimmune responses.
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