Results 201 to 210 of about 1,180,619 (263)

Clinical development of tacrolimus-resistant regulatory T cells to enable simultaneous immunosuppression and immune regulation. [PDF]

Mol Ther Adv
Zarrinrad G, Burkhardt LM, Beltran-Mestres C, Romero-Suárez S, Wagner DL, Schlickeiser S, Stein M, Wendering DJ, Carrera Diaz de la Cebosa IJ, Ehlen L, Hamm F, Kurgan GL, Durek P, Heinrich F, Giri A, Pu Y, Ou K, Hoffmann H, Muench S, Stuewe I, Dolling S, McCallion O, Kaeda J, Kath J, Schulenberg S, Wiese N, Nazari A, Peter L, Picht S, Sánchez-Peña A, Usman O, Brommel C, Turk R, Rettig G, Sturgeon M, Osborne TL, Jacobi A, Friedrich R, Kaufmann MM, Klermund J, Fink S, Templin MF, Roemhild A, Kaiser D, Klein O, Cathomen T, Mashreghi MF, Issa F, Polánsky JK, Volk HD, Schmueck-Henneresse M, Reinke P, Amini L.   +52 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells. [PDF]

Cell Death Differ
Plaza-Sirvent C, Sturm H, Nocke MK, Ghorbani F, Bessen C, Greweling-Pils MC, Floess S, Niemz J, Huysentruyt J, Tougaard P, Huehn J, Geffers R, Todt D, Vandenabeele P, Schmitz I.   +14 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Regulatory T cells and peripheral immune tolerance: key mechanisms and therapeutic strategies for cardiovascular diseases. [PDF]

Front Immunol
Lin M, Li W, Wu Y, Li M, Li Y, Zhao Y.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Regulatory T cells in cancer: from immunosuppression to therapeutic targeting. [PDF]

Front Immunol
Basurto-Olvera P, Serrano H, Maldonado-Bernal C.   +2 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Immune Imbalance in Sickle Cell Anemia: Flow Cytometric Insights Into Regulatory T Cells and Neutrophil Dynamics. [PDF]

J Clin Lab Anal
Ölçüoğlu R, Tanrıkulu F, Kılınç S, Çakmak E, Asma S, Boğa C, Özdoğu H, Pamuk İ.   +7 more
europepmc   +1 more source

Natural killer cells and regulatory T cells in aneurysmal subarachnoid hemorrhage in peripheral blood and cerebrospinal fluid - a pilot study. [PDF]

Fluids Barriers CNS
Pfnür A, Bohnacker A, Dörfer L, Ziebart A, Halbgebauer R, Huber-Lang M, Tumani H, Wirtz CR, Kapapa T.   +8 more
europepmc   +1 more source