Results 221 to 230 of about 291,895 (251)
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T-regulatory lymphocytes and chronic viral hepatitis
Expert Opinion on Biological Therapy, 2007Both hepatitis B virus (HBV) and hepatitis C virus (HCV) can cause persistent viral infection in humans. Chronic infection is associated with a risk of cirrhosis and hepatocellular carcinoma. The cause of chronic infection is unknown. A large body of evidence suggests that a failure of the adaptive immune response is critical in the establishment of ...
Simon M, Rushbrook +2 more
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The Role of Recombinant Glycodelin in the Differentiation of Regulatory T-Lymphocytes
Doklady Biological Sciences, 2022The effect of recombinant glycodelin (GdA) on the number of T-regulatory lymphocytes (Treg) in a culture of activated CD4+ lymphocytes was investigated, while simultaneously assessing the proliferative status of the cells. Recombinant GdA from E. coli and from HEK293 cells were used in the study at concentrations of 0.2; 2 and 10 µg/mL.
K Yu, Shardina +5 more
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Regulatory Role of T Lymphocytes in Atopic Dermatitis
2008Eczema does not occur in the absence of T cells. Here we provide an overview on the regulatory impact which T cells have on the establishment and maintenance of atopic dermatitis. Particularly, we outline the role of different T-helper cell subsets (i.e.
T, Werfel, M, Wittmann
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The role of regulatory t lymphocytes in asthma pathogenesis
Current Allergy and Asthma Reports, 2005Several subtypes of regulatory or suppressive T cells have been described that can prevent activation of effector T cells in vitro and in vivo in animal models. Recent evidence suggests a deficit in suppressive activity of both CD4(+)CD25(+) regulatory T cells, and interleukin (IL)-10 producing regulatory T cells may play a role in development of ...
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REGULATORY T-LYMPHOCYTES IN LYMPHOMAGENESIS
2020B-cell lymphomas are a heterogenous group of tumours that account for 85% of all non-Hodgkin lymphomas (NHL), tumours derived from cells of lymphoid lineage. B-lymphomas originate from various developmental stages of B lymphocytes. Classical Hodgkin’s lymphoma (cHL) also originates from B lymphocytes.
Gršković, Paula +5 more
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Murine CD8+ regulatory T lymphocytes: The new era
Human Immunology, 2008Regulatory T lymphocytes unequivocally play a major role in the maintenance of immunologic homeostasis. The first descriptions of regulatory T lymphocytes concerned CD8(+) cells, but this field was brought into discredit when some of its central tenets turned out to be erroneous. CD4(+) regulatory T cells took over and, with the help of newly developed
Céline, Pomié +2 more
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Role of α-fetoprotein in differentiation of regulatory T lymphocytes
Doklady Biological Sciences, 2017The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4+ lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4+ cells.
V A, Chereshnev +6 more
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Development of Thymic Regulatory T Lymphocytes
2019A healthy immune system should maintain a balance between the ability to respond to infectious agents and tumor cells at the same time that sustains self-tolerance. For this purpose, the immune system must be capable of restraining foreign antigens, stopping the immune response after the resolution of a problem and blocking autoreactivity of immune ...
Larissa Vasconcelos-Fontes +4 more
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Regulatory function of human CD4+ cytolytic T lymphocytes
Transplant Immunology, 1999Allograft rejection is mediated by both CD4+ and CD8+ T cells. The lytic function of the classic CD8+ cytolytic T lymphocytes (CTL) occurs through recognition of allogeneic major histocompatibility complex (MHC) class I on the surface of the graft. CD4+ CTL recognize MHC class II through a direct recognition pathway or an indirect pathway where MHC ...
N J, Poindexter +3 more
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Mechanisms of Surveillance of Dendritic Cells by Regulatory T Lymphocytes
2015Regulatory T cells (Tregs) are critical to maintain the homeostasis of the organism, i.e., to prevent (excessive) inflammatory reactions against self and nonself. Data in the literature suggest that a variety of suppressive mechanisms exist that may act selectively depending on the tissue environment. An interesting question is whether dendritic cells (
Maxime, Dhainaut, Muriel, Moser
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