Results 41 to 50 of about 291,895 (251)
Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4
Frontiers in Immunology, 2021 Although the human immune response to cancer is naturally potent, it can be severely disrupted as a result of an immunosuppressive tumor microenvironment.
Tobias Burkard +6 more
doaj +1 more source
Regulatory T and B lymphocytes in a spontaneous autoimmune polyneuropathy [PDF]
Clinical and Experimental Immunology, 2016 SummaryB7-2–/– non-obese diabetic (NOD) mice develop a spontaneous autoimmune polyneuropathy (SAP) that mimics the progressive form of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). In this study, we focused on the role of regulatory T cells (Tregs) and regulatory B cells (Bregs) in SAP.
S, Quan +3 more
openaire +2 more sources
Heliyon, 2020 Introduction and methods: To clarify the role of CD4+ regulatory T cells in bladder cancer, we investigated the frequency of these cells in tumor draining lymph nodes of 50 patients with bladder cancer who underwent radical cystectomy using flow ...
Ali Ariafar +5 more
doaj +1 more source
Virology Journal, 2011 Back ground Chandipura virus produces acute infection in mice. During infection drastic reduction of CD4+, CD8+ and CD19 + cell was noticed. Depletion of lymphocytes also noticed in spleen.
Shahir Prajakta, Anukumar Balakrishnan
doaj +1 more source
CD8+ T Lymphocytes: Crucial Players in Sjögren’s Syndrome
Frontiers in Immunology, 2021 Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands.
Huimin Zhou +5 more
doaj +1 more source
Functional and Molecular Comparison of Anergic and Regulatory T Lymphocytes [PDF]
The Journal of Immunology, 2006 Abstract Tolerance in vivo is maintained by multiple mechanisms that function to prevent autoimmunity. An encounter of CD4+ T cells with a circulating self-Ag leads to partial thymic deletion, the development of CD25+ regulatory T cells (Tregs), and functional anergy in the surviving CD25− population.
Birgit, Knoechel +6 more
openaire +2 more sources
Медицинский вестник Юга РоссииObjective: to evaluate the dynamics of the T- and B-cell immunity in patients with acute coronary syndrome (ACS) who have and have not had COVID-19, depending on the number of CD3+CD8+T-lymphocytes.Materials and methods: 65 men with ACS who underwent ...
E. A. Safronova +4 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A gene regulatory network armature for T lymphocyte specification [PDF]
Proceedings of the National Academy of Sciences, 2008 Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities of multiple transcription factors. To dissect the regulatory network connections that mediate this process, we have used high-resolution analysis of regulatory gene expression ...
Georgescu, Constantin +7 more
openaire +3 more sources