Extracts of Rehmanniae radix, Ginseng radix and Scutellariae radix improve glucose-stimulated insulin secretion and β-cell proliferation through IRS2 induction [PDF]
Genes & Nutrition, 2007 Recent studies have revealed that beta-cell dysfunction is an important factor in developing type 2 diabetes. beta-cell dysfunction is related to impairment of the insulin/IGF-1 signaling cascade through insulin receptor substrate-2 (IRS2). The induction of IRS2 in beta-cells plays an important role in potentiating beta-cell function and mass.
Sun Min, Park +4 more
openaire +2 more sources
Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial [PDF]
, 2016 published_or_final_versio
Chan, GCW +14 more
core +1 more source
Biological and Pharmaceutical Bulletin, 1994 Effects of 50% ethanolic extract (JR-ext) from Chinese Rehmanniae Radix (the steamed and dried root of Rehmannia glutinosa, "Jyuku-Jio" in Japanese) on the hemorheology of inflammatory, thrombosic and intact animals were examined in the in vivo models.
M, Kubo +3 more
openaire +3 more sources
In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism [PDF]
, 2016 published_or_final_versio
Tian, D, WANG, W, Zhang, Z
core +2 more sources
Prevention of Radix Rehmanniae Preparata on Glucocorticoid-Induced Osteoporosis in Rats
Chemical Engineering Transactions, 2015 The aim of present study is investigating the preventive effects of Radix Rehmanniae Preparata (PPR) on glucocoroticoids-induced osteoporosis rats. Forty-eight 3-month SD rats were divided into baseline (BAS) group, age control (CON) group, and glucocorticoids group.
Wu T.X., Zou L., He H.H., Wu K.F.
openaire +2 more sources
Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway [PDF]
Journal of Diabetes Research, 2020 Background and Aims. Radix Rehmanniae and Corni Fructus (RC) have been widely applied to treat diabetic nephropathy (DN) for centuries. But the mechanism of how RC plays the therapeutic role against DN is unclear as yet. Methods. The information about RC was obtained from a public database.
Jing Chen +7 more
openaire +3 more sources
Inhibition of Th1 and Th17 Cells by Medicinal Plants and Their Derivatives: A Systematic Review. [PDF]
, 2017 Searching for new natural drugs that are capable of targeting Th1 and Th17 may lead to development of more effective treatments for inflammatory and autoimmune diseases.
Asadi-Samani, Majid. +3 more
core +1 more source
Anti-hypertensive effects of Radix Rehmanniae and its active ingredients
Natural Product Research, 2018 Radix Rehmanniae (RR) is the root tuber of Rehmannia glutinosa Libosch. Herein, the methanol extracts of dried RR (DRR) and processed RR (PRR) were partitioned to obtain ethyl acetate, aqueous, and n-butanol layers. The angiotensin-I converting enzyme (ACE) inhibition test indicated that the ethyl acetate extracts of DRR (DRRE) and PRR (PRRE) show ...
Chiu-Haw, Chao +6 more
openaire +2 more sources
Integrating Chinese Herbal Medicine into Conventional Care Was Related to Lower Risk of Sarcopenia Among Rheumatid Arthritis Patients: A Retrospective, Population-Based Study [PDF]
, 2023 Objective: Sarcopenia is a frequently observed comorbidity of rheumatoid arthritis (RA) due to the chronic activation of the innate immune system. Accumulating evidence has indicated that Chinese herbal medicine (CHM) safely suppresses proinflammatory ...
Chen, Wei-Jen +6 more
core +2 more sources
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source