Results 211 to 220 of about 130,517 (289)

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

Cancer Science, EarlyView.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut, Sébastien Martinez, Ludivine Pruvost, Louisane Eve, Rania El‐Botty, Laura Sourd, Elodie Montaudon, Ahmed Dahmani, Heloise Derrien, Stéphanie Sentis, Coralie Poulard, Elisabetta Marangoni, Olivier Trédan, Muriel Le Romancer   +13 more
wiley   +1 more source

Enhancement of nutritional and textural properties of restructured jerky with duck blood powder for meal kit applications. [PDF]

Food Sci Anim Resour
Ku SK, Cha JY, Kim YJ, Choi YS.
europepmc   +1 more source

SMURF1 Regulates CTCF‐HOXA10 Axis and Promotes Tumor Progression in Nasopharyngeal Carcinoma

Cancer Science, EarlyView.
Our study showed that SMURF1 was significantly upregulated in nasopharyngeal carcinoma (NPC) and promoted tumor progression and SMURF1 promoted K48‐linked ubiquitination degradation of CTCF. ABSTRACT The aberrant upregulation of Homeobox A10 (HOXA10) has been implicated in the progression of nasopharyngeal carcinoma (NPC), but the mechanisms driving ...
Ying Jin, Tian Zhang, Zhimin Wu, Yuanshan Liang, Yiting Jiang, Guodong Yu   +5 more
wiley   +1 more source

Reconstruction of the transcriptional regulatory networks in the kidney of desert-adapted species. [PDF]

Commun Biol
Alvira-Iraizoz F, Gillard BT, Pauža AG, Lin P, Paterson A, Burger PA, Ali MH, Amor N, Alagaili AN, Adem A, Murphy D, Greenwood MP.   +11 more
europepmc   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Thin-Layer Drying Kinetics and Quality Attributes of Apple Pomace Powders from Different Varieties. [PDF]

Foods
Ceclu L, Corbu AR, Rumeus I, Cicanci A, Blejan AM, Vîșcu I, Nour V.   +6 more
europepmc   +1 more source

Renal tubular acidosis in a mule mare

Equine Veterinary Education, EarlyView.
Summary Renal tubular acidosis (RTA) in horses is differentiated into type I (distal) and type II (proximal) forms. We report the diagnostic evaluation and treatment of type I RTA in a 13‐year‐old mule mare that was referred because of lethargy and inappetence of several weeks' duration as well as lack of manure, anorexia and mild colic for 3 days.
L. Kummer, K. Lohmann, C. Arnold
wiley   +1 more source

Defying Death: A Multi-Omics Approach to Understanding Desiccation Tolerance and Senescence in <i>Eragrostis nindensis</i>. [PDF]

Plants (Basel)
Madden CF, Williams B, Mundree S, Acket S, Ruelland E, Hilhorst HWM, Farrant JM.   +6 more
europepmc   +1 more source

Establishment of an MRI‐Based Diagnostic Approach to Identify Critical Pulpal Inflammation Zones in a Rat Caries‐Derived Pulpitis Model

International Endodontic Journal, EarlyView.
ABSTRACT Aim To establish a magnetic resonance imaging (MRI)‐based diagnostic approach for identifying ‘critical pulpal inflammation’ zones in a rat model of caries‐derived pulpitis. Methodology Caries‐derived pulpitis was induced in the molars of Sprague–Dawley rats using the caries‐derived pulpitis model.
Kiichi Moriyama, Motoki Okamoto, Masakatsu Watanabe, Hailing Huang, Koki Nakatani, Shigeyoshi Saito, Yusuke Takahashi, Mikako Hayashi   +7 more
wiley   +1 more source