Kappa free light chain index as a diagnostic biomarker in multiple sclerosis: a real-world investigation [PDF]
Journal of Neurochemistry, Volume 159, Issue 3, Page 618-628, November 2021., 2021 Kappa free light chain (KFLC)-index, a measure for intrathecal production of free kappa chains, has been increasingly recognized for its diagnostic potential in multiple sclerosis (MS) as a quantitative alternative to IgG oligoclonal-bands (OCBs).
Axelsson, M +6 more
core +2 more sources
CSF/serum ratios: modern approach to assess intrathecal response [PDF]
Инфекция и иммунитетCSF/serum ratios are the quotients of protein concentrations between the cerebrospinal fluid and blood serum. This method provides an objective assessment of proteins amount and origin in the cerebrospinal fluid.
Alexandra M. Deomkina +3 more
doaj +2 more sources
Importance of the quotient of albumin, quotient of immunoglobulin G and Reibergram in inflammatory neurological disorders with disease‐specific patterns of blood–brain barrier permeability [PDF]
Neurology and Clinical Neuroscience, 2015 AbstractBackgroundThere are still insufficient quantitative comparisons of phase‐dependent blood–brain barrier permeability among inflammatory central nervous system disorders.AimBy using the Reibergram (2‐D diagram of the quotient of albumin and quotient of immunoglobulin G), we visually compared the extent of blood–brain barrier permeability among ...
Tetsuya Akaishi, Ichiro Nakashima
exaly +2 more sources
Real-World Laboratory Analysis of Molecular Biomarkers in Multiple Sclerosis Centers in Central-Eastern European Countries Covering 107 Million Inhabitants. [PDF]
Int J Mol SciA multicenter molecular biomarker survey was conducted in Multiple Sclerosis (MS) centers across Central-Eastern European countries, encompassing a population of 107 million. Our aim was to provide a "snapshot" for future studies investigating the use of
Járdánházy A +18 more
europepmc +3 more sources
Intrathecal IgG Synthesis: A Resistant and Valuable Target for Future Multiple Sclerosis Treatments [PDF]
Multiple Sclerosis International, Volume 2015, Issue 1, 2015., 2015 Intrathecal IgG synthesis is a key biological feature of multiple sclerosis (MS). When acquired early, it persists over time. A growing body of evidence suggests that intrathecal Ig-secreting cells may be pathogenic either by a direct action of toxic IgG
Mickael Bonnan
core +4 more sources
Reibergram and Oligoclonal Bands in Diagnosis of Multiple Sclerosis
Medicinski Arhiv = Medical Archives = Archives De Médecine, 2012 In this study authors have analyzed the correlation between the IgG immunoglobulins in cerebrospinal fluid and the findings of oligoclonal bands on gel. Immunoglobulin IgG in cerebrospinal fluid (CSF) can be detected in neurological diseasses (infections and inflammatory neurological diseases and in demyelinating diseases, like multiple sclerosis (MS)).
Karamehic, Jasenko +11 more
exaly +3 more sources
Neuroimmunology of meningoencephalitis by Cryptococcus neoformans. A case report [PDF]
Revista Habanera de Ciencias Médicas, 2016 Introduction: Meningitis/meningoencephalitis is a non-frequent central nervous system infection produced by Cryptococcus neoformans. Objective: To show the neuroimmunological response using reibergram in a patient with chronic meningoencephalitis due to
Bárbara Padilla-Docal +2 more
doaj +2 more sources
Intrathecal synthesis of IgE in children with eosinophilic meningoencephalitis caused by
Cerebrospinal Fluid Research, 2008 Background Eosinophilic meningoencephalitis caused by the helminth Angiostrongylus cantonensis, is an emerging infectious disease in America. The objective of this paper was to determine if the intrathecal synthesis of immunoglobulin E is produced during
Barroso Jesús +5 more
doaj +2 more sources
The use of Reibergram in Cuban neuroimmunology
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018 Cerebrospinal fluid (CSF) is an indispensable source of information for the diagnosis and progress of numerous neurological diseases. Reibergrams are diagrams in which the functionality of the blood-CSF barrier and the intrathecal synthesis of ...
Alvaro Pérez-Pérez
doaj +1 more source
Adrenomyeoloneuropathy, X-linked adrenoleukodystrophy phenotype. A Case Report [PDF]
Revista Habanera de Ciencias Médicas, 2018 Introduction: Adrenomyeoloneuropathy is a peroxisomal disease with a sex-linked pattern of inheritance. It is a phenotypic variety of X-linked adrenoleukodystrophy; this last one is also a cause of adrenal insufficiency.
Alberto Juan Dorta-Contreras +2 more
doaj +2 more sources