Anti-JCV antibody index does not change during ocrelizumab-treatment [PDF]
Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2020 Objective To prospectively assess anti-JCV antibody index (AI) and its relationship to immunoglobulin levels in ocrelizumab-treated MS patients. Methods Monocentric prospective observational study over 24 months assessing anti-JCV AI and immunoglobulin ...
Torge Rempe +3 more
doaj +6 more sources
Stability and predictive value of anti-JCV antibody index in multiple sclerosis: A 6-year longitudinal study. [PDF]
PLoS ONE, 2017 BACKGROUND:Risk of natalizumab-related progressive multifocal leukoencephalopathy is associated with the presence of anti-JC-virus (JCV) antibodies.
Harald Hegen +7 more
doaj +5 more sources
Impact of Disease-Modifying Treatments on the Longitudinal Evolution of Anti-JCV Antibody Index in Multiple Sclerosis [PDF]
Frontiers in Immunology, 2018 Background: Risk of natalizumab-related progressive multifocal leukoencephalopathy is associated with the presence of anti-JC-virus (JCV) antibodies.Objective: To investigate the impact of disease-modifying treatments (DMT) on the longitudinal evolution ...
Harald Hegen +8 more
doaj +6 more sources
Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis [PDF]
Biomedicines, 2022 Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy.
Luigi Caputi +9 more
doaj +3 more sources
Improved therapeutic index of an acidic pH-selective antibody [PDF]
mAbs, 2022 Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment.
Peter S. Lee +17 more
doaj +3 more sources
Therapeutic index improvement of antibody-drug conjugates
mAbs, 2023 The commentary by Colombo and Rich recently published in Cancer Cell provides a timely and comprehensive review of the clinical maximum tolerated doses (MTDs) of antibody−drug conjugates (ADCs) and their corresponding small molecules/chemotherapies.
Hans-Peter Gerber +2 more
doaj +3 more sources
The Effect of Ocrelizumab on Anti‐JC Virus Antibody Index [PDF]
Brain and BehaviorPurpose/Introduction The anti‐JC virus (JCV) antibody index is used to stratify the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS), particularly with natalizumab therapy.
Akash Virupakshaiah +8 more
doaj +2 more sources
The recomBead Borrelia antibody index, CXCL13 and total IgM index for laboratory diagnosis of Lyme neuroborreliosis in children. [PDF]
Eur J Clin Microbiol Infect Dis, 2017 For laboratory diagnostics of Lyme neuroborreliosis (LNB), the recomBead Borrelia antibody index (AI) assay has shown promising results in a mixed age population, but has not previously been evaluated with specific focus on paediatric patients. The aim of the study was to evaluate the recomBead Borrelia AI assay in cerebrospinal fluid (CSF) for the ...
Skogman BH +3 more
europepmc +6 more sources
IgG intrathecal synthesis and specific antibody index in patients with neurocysticercosis [PDF]
Arquivos de Neuro-Psiquiatria, 2002 We analyzed cerebrospinal fluid (CSF) and blood serum from 55 patients with neurocysticercosis (NC) at different clinical stages. According to inflammatory activity in the CSF, three stages were identified: (1) reactive, when there was at least an ...
Luís R. Machado +6 more
doaj +6 more sources
Definite neuroborreliosis with atypical antibody-profiles: a case report [PDF]
Journal of Medical Case ReportsBackground According to European Academy of Neurology guidelines, a positive Borrelia burgdorferi antibody index is required for diagnosing definite Lyme neuroborreliosis. Exceptions to the typical antibody production may be seen in the earlier phases of
Ingerid Skarstein +9 more
doaj +2 more sources