Anti-JCV antibody index does not change during ocrelizumab-treatment [PDF]
Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2020 Objective To prospectively assess anti-JCV antibody index (AI) and its relationship to immunoglobulin levels in ocrelizumab-treated MS patients. Methods Monocentric prospective observational study over 24 months assessing anti-JCV AI and immunoglobulin ...
Torge Rempe +3 more
doaj +7 more sources
Stability and predictive value of anti-JCV antibody index in multiple sclerosis: A 6-year longitudinal study. [PDF]
PLoS ONE, 2017 BACKGROUND:Risk of natalizumab-related progressive multifocal leukoencephalopathy is associated with the presence of anti-JC-virus (JCV) antibodies.
Harald Hegen +7 more
doaj +5 more sources
Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis [PDF]
Biomedicines, 2022 Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy.
Luigi Caputi +9 more
doaj +3 more sources
Therapeutic index improvement of antibody-drug conjugates
mAbs, 2023 The commentary by Colombo and Rich recently published in Cancer Cell provides a timely and comprehensive review of the clinical maximum tolerated doses (MTDs) of antibody−drug conjugates (ADCs) and their corresponding small molecules/chemotherapies.
Hans-Peter Gerber +2 more
doaj +4 more sources
Impact of Disease-Modifying Treatments on the Longitudinal Evolution of Anti-JCV Antibody Index in Multiple Sclerosis [PDF]
Frontiers in Immunology, 2018 Background: Risk of natalizumab-related progressive multifocal leukoencephalopathy is associated with the presence of anti-JC-virus (JCV) antibodies.Objective: To investigate the impact of disease-modifying treatments (DMT) on the longitudinal evolution ...
Harald Hegen +8 more
doaj +3 more sources
Improved therapeutic index of an acidic pH-selective antibody [PDF]
mAbs, 2022 Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment.
Peter S. Lee +17 more
doaj +4 more sources
The recomBead Borrelia antibody index, CXCL13 and total IgM index for laboratory diagnosis of Lyme neuroborreliosis in children. [PDF]
Eur J Clin Microbiol Infect Dis, 2017 For laboratory diagnostics of Lyme neuroborreliosis (LNB), the recomBead Borrelia antibody index (AI) assay has shown promising results in a mixed age population, but has not previously been evaluated with specific focus on paediatric patients.
Skogman BH +3 more
europepmc +7 more sources
The Effect of Ocrelizumab on Anti‐JC Virus Antibody Index [PDF]
Brain and BehaviorPurpose/Introduction The anti‐JC virus (JCV) antibody index is used to stratify the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS), particularly with natalizumab therapy.
Akash Virupakshaiah +8 more
doaj +3 more sources
IgG intrathecal synthesis and specific antibody index in patients with neurocysticercosis [PDF]
Arquivos de Neuro-Psiquiatria, 2002 We analyzed cerebrospinal fluid (CSF) and blood serum from 55 patients with neurocysticercosis (NC) at different clinical stages. According to inflammatory activity in the CSF, three stages were identified: (1) reactive, when there was at least an ...
Luís R. Machado +6 more
doaj +7 more sources
Comparison of three serological chemiluminescence immunoassays for SARS-CoV-2, and clinical significance of antibody index with disease severity. [PDF]
PLoS One, 2021 Background The clinical significance of the quantitative value of antibodies in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains mostly unidentified.
Lee N, Jeong S, Park MJ, Song W.
europepmc +2 more sources