Results 91 to 100 of about 1,157,336 (324)
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
New Phytologist, 2013 SummaryA major goal of evolutionary biology is to understand how diverging populations become species. The evolution of reproductive isolation (RI) halts the genomic homogenization caused by gene flow and recombination, and enables differentiation and local adaptations to become fixed between newly forming species. Selection can favor the strengthening
openaire +3 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Distributional Reinforcement Learning with Quantile Regression
, 2017 In reinforcement learning an agent interacts with the environment by taking actions and observing the next state and reward. When sampled probabilistically, these state transitions, rewards, and actions can all induce randomness in the observed long-term
Bellemare, Marc G. +3 more
core +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Mechanical response of composite materials with through-the-thickness reinforcement [PDF]
An experimental investigation was conducted to identify the key geometrical parameters and quantify their influence on the mechanical response of through-the-thickness (TTT) reinforced composite materials.
Dickinson, Larry C., Farley, Gary L.
core +1 more source
On the speed of once-reinforced biased random walk on trees
, 2018 We study the asymptotic behaviour of once-reinforced biased random walk (ORbRW) on Galton-Watson trees. Here the underlying (unreinforced) random walk has a bias towards or away from the root.
Collevecchio, Andrea +2 more
core +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Urban LifelineBuried pipeline systems are vulnerable to joint damage in earthquakes. Previous studies have shown that bellows joints are effective in increasing deformation capacity and reducing the axial force of the main pipeline.
Fang-fang Li +5 more
doaj +1 more source