Results 181 to 190 of about 17,592 (257)

Evaluating the combined effects of renewal and response-dependent reinstatement. [PDF]

J Exp Anal Behav
Kimball RT, Kranak MP, Bernal-Gamboa R, Gámez AM, Nieto J, Mason TA.   +5 more
europepmc   +1 more source

Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages. [PDF]

Front Behav Neurosci
Martínez-Caballero MÁ, Calpe-López C, García-Pardo MP, Arenas MC, Manzanedo C, Aguilar MA.   +5 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Glycyrrhizic acid mitigates the risk of nicotine addiction and nicotine withdrawal: The modulation of kynurenine aminotransferase II. [PDF]

J Adv Pharm Technol Res
Rahmadi M, Aryani T, Anggraini D, Maheswara SR, Rahmaningtyas SD, Nurhan AD.   +5 more
europepmc   +1 more source

Subregion‐specific perineuronal net remodelling in the dorsal hippocampus drives vulnerability and resilience to chronic stress: The role of venlafaxine treatment

British Journal of Pharmacology, EarlyView.
Background and Purpose Neuronal plasticity enables the brain to adapt to internal and external demands by dynamically regulating synaptic connectivity and emotional circuitry. Impaired neuroplasticity represents a core pathophysiological framework of major depressive disorder, one of the leading causes of disability worldwide. Chronic stress is a major
Paola Brivio, Arianna Palumbo, Maria Teresa Gallo, Filippo Umberto Tancredi Veronesi, Giorgia Cortinovis, Piotr Gruca, Magdalena Lason, Ewa Litwa, Dominika Biala, Fabio Fumagalli, Mariusz Papp, Francesca Calabrese   +11 more
wiley   +1 more source

Functional interaction between orexin/dynorphin transmission in the posterior paraventricular nucleus of the thalamus following alcohol dependence: mediation of alcohol-seeking behavior. [PDF]

Front Pharmacol
Flores-Ramirez FJ, Pascasio G, Martin-Fardon R.   +2 more
europepmc   +1 more source

Intermittent cocaine use patterns, not total intake, predict cue‐induced drug seeking in rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cocaine‐associated cues trigger relapse to drug use in humans and animal models. In rats, long daily cocaine access (4–6 vs. 1–2 h) increases drug self‐administration and cue‐induced cocaine seeking, suggesting that greater intake promotes relapse.
Amélie Mainville‐Berthiaume, Hajer Algallal, Salomé Dupuis, Sema Abu Shamleh, Coralie Godbout, Vincent Jacquemet, Anne‐Noël Samaha   +6 more
wiley   +1 more source

Activation of Insula-Accumbal Projection Neurons Is Required for Relapse-Like Behaviour Following Opioid Self-Administration. [PDF]

Addict Biol
Clarke RE, Pagoota BE, Dinu IE, Paniccia JE, Tsyrulnikov AC, Westphal AM, Baek J, Scofield MD, Otis JM.   +8 more
europepmc   +1 more source

Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine

British Journal of Pharmacology, EarlyView.
Background and Purpose The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro‐nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this ...
Simon Akerman, Ana Belen Salinas‐Abarca, Wei Guo, Daniela Salvemini, Marcela Romero‐Reyes   +4 more
wiley   +1 more source

Behavioral impact of chemogenetic manipulations of 5-HT DRN neurons in transgenic Tph2-iCre rats. [PDF]

Psychopharmacology (Berl)
McCloskey NS, Li C, Kirby LG.
europepmc   +1 more source