Results 191 to 200 of about 17,592 (257)

UBE2C‐Mediated CD147‐CTLA‐4 Axis Promotes T Cell Exhaustion and Immunosuppressive Microenvironment in Bladder Cancer

Cancer Science, EarlyView.
UBE2C upregulates cellular CD147 and enhances its release into the tumor microenvironment both as soluble CD147 (sCD147) and packaged within tumor‐derived exosomes. These CD147‐bearing signals induce T‐cell exhaustion, marked by elevated CTLA‐4 expression and reduced secretion of effector cytokines (IFN‐γ, TNF‐α, TGF‐β), ultimately diminishing CD8+ T ...
Xuwei Hong, Ting Hong, Xinyu Liu, Peixiu Yao, Weiqiang Lin, Guoyuan Liu, Huihong Guan, Yonghai Zhang   +7 more
wiley   +1 more source

Misclassification in memory modification in <i>App^NL-G-F</i> knock-in mouse model of Alzheimer's disease. [PDF]

Elife
Huang ML, Suzuki Y, Sasaguri H, Saito T, Saido TC, Imayoshi I.   +5 more
europepmc   +1 more source

FDX1 Depletion Activates CD8+ T Cell Antitumor Immunity by Promoting DMBT1 Secretion in Cuproptosis of Colorectal Cancer

Cancer Science, EarlyView.
Elesclomol‐induced cuproptosis potently activates both innate and adaptive antitumor immunity, especially CD8+ T cell immunity. FDX1 serves as a central regulator of CD8+ T cell functionality through DMBT1 downregulation during cuproptosis in colorectal cancer.
Jieqiong Wu, Zaixi Lian, Mingzhou Li, Xingtu Qin, Xiaoyu Lei, Lihua Yang, Lin Bing, Qiuyue Li, Lingyan Zhou, Zhiyang Ma, Xuemei Xu, Jinghao Huang, Zilong Chen, Lijie Chen, Lingjie Zhang, Zhiyuan Xiao, Xiangyu Jian, Xiaoqin Zhang, Yanqing Ding, Yaping Ye, Li Liang, Hongli Jiao, Shuyang Wang   +22 more
wiley   +1 more source

Verbal working memory performance and proactive interference are largely unaffected by matching font color reinstatement. [PDF]

Front Psychol
Festini SB.
europepmc   +1 more source

A Splitting Architecture for Exact Reduced Coulomb Friction

Computer Graphics Forum, EarlyView.
Abstract Existing approaches to frictional contact dynamics typically either modify the Coulomb law to improve numerical robustness or solve the exact law in a fully coupled monolithic form. However, in its reduced form, exact Coulomb friction can be written as a cone complementarity problem with an augmented velocity, which reveals a natural split ...
Hongcheng Song, Ye Fan, Uri M. Ascher, Dinesh K. Pai   +3 more
wiley   +1 more source

Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice. [PDF]

Alcohol
Nothem MA, Side CM, Tran SC, Brar A, Buck LA, Barker JM.   +5 more
europepmc   +1 more source

PACAP Signalling Network in the Nucleus Accumbens Core Regulates Reinstatement Behaviour in Rat. [PDF]

Addict Biol
Bose S, Simandl G, Hess EM, Kong L, Raddatz NJ, Maunze B, Choi S, Baker DA.   +7 more
europepmc   +1 more source

Amygdala transcranial ultrasound stimulation disrupts threat acquisition and extinction learning. [PDF]

Sci Adv
Fonzo GA, LaBar KS.
europepmc   +1 more source

The role of the adenosinergic pathway in resistance to hypomethylating agents in patients with high‐risk myelodysplastic syndromes

British Journal of Haematology, EarlyView.
George Vrachiolias, Eleftheria Lamprianidou, Athanasios Tasis, Theodoros Spyropoulos, Despoina Dimitriou, Chryssa Kymparidou, Christina Misidou, Konstantinos Liapis, Emmanouil Spanoudakis, Maria Koffa, Menelaos Papoutselis, Iliana Stamatiou, Elsa Bernard, Elli Papaemmanuil, Ioannis Mitroulis, Ioannis Kotsianidis   +15 more
wiley   +1 more source

The role of the prelimbic cortex to nucleus accumbens core projection in the reinstatement of cocaine-seeking after cocaine-alcohol polysubstance use. [PDF]

Neuropsychopharmacology
Mesa JR, Dick SY, Greenan K, Wu L, Knackstedt LA.   +4 more
europepmc   +1 more source