Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Neural correlates and reinstatement of recent and remote memory in children and young adults. [PDF]
ElifeSchommartz I +6 more
europepmc +1 more source
Cancer Science, EarlyView.UBE2C upregulates cellular CD147 and enhances its release into the tumor microenvironment both as soluble CD147 (sCD147) and packaged within tumor‐derived exosomes. These CD147‐bearing signals induce T‐cell exhaustion, marked by elevated CTLA‐4 expression and reduced secretion of effector cytokines (IFN‐γ, TNF‐α, TGF‐β), ultimately diminishing CD8+ T ...
Xuwei Hong +7 more
wiley +1 more source
From Innovation to Validation: Strengthening Interventional Radiology Through Data
Journal of Medical Imaging and Radiation Oncology, EarlyView.
Kaiwen Cabbabe +3 more
wiley +1 more source
A Critical Review of the 2025 RSHE Guidance and Alternative Approach Framed in Safe Uncertainty
Children &Society, EarlyView.ABSTRACT This policy review critically examines the English government's 2025 statutory guidance on Relationships Education, Relationship and Sex Education and Health Education (RSHE), analysing its educational assumptions, strengths and limitations through the lens of safe uncertainty.
Emily Setty, Jonny Hunt
wiley +1 more source
Uncovering correlates of decline and critical refuges for a threatened terrestrial mammal
Conservation Biology, EarlyView.Abstract Globally, the geographic ranges of numerous species are contracting. Identifying spatiotemporal patterns of threat impact can illuminate why species decline in some parts of their range but persist in others. We developed a correlative approach to identify species’ response thresholds and locate ecological refuge areas associated with ...
Natalya M. Maitz +5 more
wiley +1 more source
Marked sex differences are observed in heroin acquisition and affective states in rats but converge to similar levels of footshock stress-induced reinstatement. [PDF]
Psychopharmacology (Berl)Deckers C, Ahmed Z, Li C, Kirby LG.
europepmc +1 more source
Twelve principles for successful governance of community‐based coastal marine restoration
Conservation Biology, EarlyView.Abstract Global agreements, such as the Global Biodiversity Framework, call for urgent, large‐scale action to halt biodiversity loss through a whole‐of‐society approach. Community‐based restoration can play a crucial role in achieving this goal, yet there remains limited understanding of what makes these projects effective and sustainable.
Michelle M. Holian +2 more
wiley +1 more source
Cannabis intoxication does not impair eyewitness recall with the Sketch Cognitive Interview but increases confidence in lineup errors. [PDF]
Sci RepKloft-Heller L +5 more
europepmc +1 more source