Predicting the On-Study Relapse Rate for Multiple Sclerosis Patients in Clinical Trials [PDF]
, 2005 Background: The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors ...
Heigenhauser, L. +4 more
core +2 more sources
Outcome of MS relapses in the era of disease-modifying therapy
BMC Neurology, 2017 Background In multiple sclerosis (MS), neurological disability results from incomplete remission of relapses and from relapse-independent progression.
Muriel Stoppe +3 more
doaj +1 more source
Management of Vulvovaginal Cellular Angiofibroma: A Single-Center Experience
Frontiers in Surgery, 2022 ObjectiveThe study aimed to explore the clinical characteristics, treatment, and prognosis of cellular angiofibroma in females.MethodsWe performed a retrospective study in patients with vulvovaginal cellular angiofibroma treated at Peking Union Medical ...
Zhen Yuan +6 more
doaj +1 more source
Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors [PDF]
, 2002 FLT3 mutations, either internal tandem duplications (ITDs) or aspartate residue 835 (D835) point mutations, are present in approximately one third of patients with acute myeloid leukemia (AML) and have been associated with an increased relapse rate.
Bowen, D.T. +5 more
core +1 more source
Dentistry Journal, 2020 The aim of this study is to present an oral device that improves splanchnocranium stability after osteodistraction in children treated for correction of craniofacial malformations. When removal of the distraction device before the end of the treatment is
Giulio Gasparini +13 more
doaj +1 more source
CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma
OncoImmunology, 2022 B cell lymphoma therapy has been transformed by CD19-targeting cellular therapeutics that induce high clinical response rates and impressive remissions in relapsed and refractory patients.
Lihe Su +4 more
doaj +1 more source
An activation-clearance model for Plasmodium vivax malaria [PDF]
Bull Math Biol 82, 32 (2020), 2021 Malaria is an infectious disease with an immense global health burden. Plasmodium vivax is the most geographically widespread species of malaria. Relapsing infections, caused by the activation of liver-stage parasites known as hypnozoites, are a critical feature of the epidemiology of Plasmodium vivax.
arxiv +1 more source
A prospective evaluation of the predictive value of faecal calprotectin in quiescent Crohn’s disease [PDF]
, 2014 Background: The faecal calprotectin (FC) test is a non-invasive marker for gastrointestinal inflammation. Aim: To determine whether higher FC levels in individuals with quiescent Crohn’s disease are associated with clinical relapse over the ensuing 12 ...
Allan J. Morris +50 more
core +1 more source
Circulating microRNA associated with future relapse status in major depressive disorder
Frontiers in Psychiatry, 2022 Major depressive disorder (MDD) is an episodic condition with relapsing and remitting disease course. Elucidating biomarkers that can predict future relapse in individuals responding to an antidepressant treatment holds the potential to identify those ...
Qingqin S. Li +5 more
doaj +1 more source
Predictors of time to relapse in amphetamine-type substance users in the matrix treatment program in Iran : a Cox proportional hazard model application [PDF]
, 2016 Background: The aim of this study was to determine which predictors influence the risk of relapse among a cohort of amphetamine-type substance (ATS) users in Iran.
Moeeni, Maryam +5 more
core +2 more sources