Results 161 to 170 of about 4,730,453 (227)

Advancing In Vivo Chimeric Antigen Receptor T‐Cell Engineering to Accelerate Clinical Translation

MedComm, Volume 7, Issue 10, October 2026.
In vivo CAR‐T cell generation directly engineers endogenous T cells using pre‐manufactured gene delivery vectors that target T cells and deliver CAR‐encoding genetic material. The resulting CAR‐T cells expand in vivo and mediate antigen‐specific cytotoxicity.
Zhenxin Bai, Ming Yi, Shengtao Hu, Dixuan Xue, Luxin Wei, Lifeng Zhang, Zhijun Dai   +6 more
wiley   +1 more source

Brain atrophy rates vary with age in relapsing-remitting multiple sclerosis. [PDF]

J Neurol Neurosurg Psychiatry
Kaçar S, van Nederpelt DR, Jelgerhuis JR, Coerver EME, Killestein J, Sormani MP, Ciccarelli O, Arnold DL, van Kempen ZLE, Uitdehaag BMJ, Barkhof F, Koch MW, Schoonheim MM, Eshaghi A, Strijbis EMM.   +14 more
europepmc   +1 more source

Frailty and Fitness in Older Adults With Acute Myeloid Leukemia: From Chronological Age to Multiparametric Assessment

European Journal of Haematology, Volume 117, Issue 4, Page 787-798, October 2026.
ABSTRACT Acute Myeloid Leukemia predominantly affects older adults, who often present with comorbidities, functional impairment, and frailty, limiting eligibility for intensive chemotherapy or allogeneic transplantation. Historically, treatment options were restricted to hypomethylating agents, low‐dose cytarabine, hydroxyurea, or supportive care, with
Antonella Bruzzese, Enrica Antonia Martino, Santino Caserta, Maria Eugenia Alvaro, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Ernesto Vigna, Massimo Gentile   +11 more
wiley   +1 more source

Digital monitoring of disease activity in relapsing-remitting multiple sclerosis. [PDF]

J Neurol
Molenaar PCG, de Jong DJ, Hof SN, van Oirschot P, Bucur IG, Lam KH, Moraal B, Heskes TM, de Groot V, Uitdehaag BMJ, de Jong BA, Twisk JWR, Strijbis EMM, Killestein J.   +13 more
europepmc   +1 more source

Serum GFAP and Age Accurately Distinguish AQP4‐IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

European Journal of Neurology, Volume 33, Issue 10, October 2026.
After a recent NMOSD attack, serum GFAP and age together provide a simple and powerful way to distinguish AQP4‐IgG NMOSD from MOGAD and related disorders. In 240 patients evaluated within 90 days of an attack from a 640‐patient cohort, this combination achieved high diagnostic accuracy (AUC up to 0.95).
Manon Rival, Fabien Rollot, Sabine Laurent‐Chabalier, Romain Casey, Illiasse El Bahi, Guillaume Brocard, Romain Marignier, Sophie Trouillet‐Assant, Sandra Vukusic, Agnès Fromont, David Axel Laplaud, Guillaume Mathey, Elisabeth Maillart, Laure Michel, Aurélie Ruet, Pierre Labauge, Xavier Ayrignac, Hélène Zephir, Jonathan Ciron, Jérôme de Sèze, Arnaud Kwiatkowski, Caroline Papeix, Pierre Branger, Christine Lebrun‐Frenay, Eric Berger, Pierre Clavelou, Olivier Heinzlef, Jean Pelletier, Abdullatif Al‐Khedr, Olivier Casez, Bertrand Bourre, Alain Créange, Thomas David, Laurent Magy, Jean‐Philippe Camdessanche, Inès Doghri, Amélie Dos Santos, Thibault Mura, Hanane Agherbi, Eric Thouvenot, for the OFSEP Group and NOMADMUS Investigators, Nicolas Collongues, Céline Cognet, Mireille Desille‐Dugast, Nathalie Dufay, Mathilde Berthome, Michael Hisbergues, Sylvain Lehmann, Laurence Liang, Céline Loiseau, Julie Marechal, Estelle Nisse, Françoise Durand‐Dubief, François Cotton, Bertrand Audoin, Mikael Cohen, Nicolas Collongues, Romain Deschamps   +57 more
wiley   +1 more source

Study on the relationship between disease progression and changes in Th17/Treg levels in patients with relapsing-remitting multiple sclerosis. [PDF]

Front Neurol
Yang J, Xue Q, Wang X, Song A.
europepmc   +1 more source

Dissociating Fatigue and Fatigability in Multiple Sclerosis: The Role of Cognitive Processing Speed

European Journal of Neurology, Volume 33, Issue 10, October 2026.
In people with multiple sclerosis, task‐induced fatigability normalized once cognitive load was calibrated to each patient's processing speed, whereas perceived fatigue remained elevated. Long‐term fatigue—but not fatigability—was associated with putamen and callosal atrophy, an association mediated by slowed processing speed, which emerges as a key ...
Jeromy Hrabovecky, Sophie Elands, Guillermo Borragán, Antonin Rovai, Nicolas Gaspard, Philippe Peigneux, Xavier De Tiège, Hichem Slama, Mélanie Strauss   +8 more
wiley   +1 more source

Ocrelizumab-Induced Brain Volume Dynamics in Relapsing-Remitting Multiple Sclerosis. [PDF]

Pharmaceuticals (Basel)
De Masi R, Orlando S.
europepmc   +1 more source

Advances in the treatment of systemic lupus erythematosus: Biologicals, small‐molecular agents, and cell‐depleting therapies coming to the clinic

Journal of Internal Medicine, Volume 300, Issue 4, Page 461-479, October 2026.
Abstract Systemic lupus erythematosus (SLE; lupus) remains a particular challenge for the practicing clinician on account of its chronic undulating and unpredictable course, its diverse manifestations, and—until recently—limited treatment options all associated with considerable downsides.
Ronald van Vollenhoven
wiley   +1 more source

Adjunctive Dulaglutide in Relapsing-Remitting Multiple Sclerosis: A Randomized Open-Label Proof-of-Concept Trial. [PDF]

Neurol Ther
Šiarnik P, Rádiková Ž, Kollár B, Kutšálová M, Penesová A, Havranová A, Imrich R, Vlček M, Žitňanová I, Krastev G, Turčáni P.   +10 more
europepmc   +1 more source