Results 151 to 160 of about 4,730,453 (227)

Pharmacokinetic-Pharmacodynamic Modelling of Repeated Ocrelizumab Dosing in Relapsing-Remitting Multiple Sclerosis. [PDF]

Clin Pharmacokinet
Serkland TT, Oma AF, Hallin EI, Øverås MH, Nygaard GO, Myhr KM, Torkildsen Ø, Röblitz S, Skrede S.   +8 more
europepmc   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

Quality of life is decreased in persons with relapsing-remitting multiple sclerosis experiencing progression independent of relapse activity

Introduction: Reduced quality of life (QoL) is an early feature of multiple sclerosis (MS). The effect of progression independent of relapse activity (PIRA) on QoL is poorly investigated.
Sandgren, Sofia,, Novakova, Lenka,, Rosenstein, Igal,, Lycke, Jan,, Lindberg, Sarah,, Axelsson, Markus,   +5 more
core   +1 more source

Mediterranean Diet and Micronutrient Adequacy in Relation to Relapsing-Remitting Multiple Sclerosis Risk: A Case-Control Study. [PDF]

Health Sci Rep
Ahmadi-Khorram M, Hatami A, Shahraki Jazinaki M, Aali Y, Nojoumi M, Keykhaei F, Jafarzadeh Esfehani A, Nematy M.   +7 more
europepmc   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Impaired cerebrovascular reactivity is associated with disability and cognitive performance in relapsing-remitting multiple sclerosis. [PDF]

Neurol Sci
Ntais E, Kostadima V, Haski A, Tsamis K, Giannopoulos S, Konitsiotis S.   +5 more
europepmc   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Subcutaneous natalizumab administration in relapsing-remitting multiple sclerosis: results of EASIER 2 study. [PDF]

J Neurol
Filippi M, Grimaldi LME, Brescia Morra V, Conte A, Cordioli C, Totaro R, Lus G, Rini A, Marinelli F, Valentino P, Perini P, Marfia GA, Valente M, Malucchi S, Zanetta C, Pradelli L, Perini D, Santoni L, EASIER 2 study working Group.   +18 more
europepmc   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

Retinal Layer Thickness for Risk Stratification of Progression Independent of Relapse Activity in Relapsing-Remitting Multiple Sclerosis. [PDF]

Brain Behav
Braginets A, Oertel FC, Strauß EM, Leutloff C, Schmitz-Hübsch T, Paul F, Asseyer S, Wicklein R, Hemmer B, Ruprecht K, Zimmermann HG, Knier B, Lin TY.   +12 more
europepmc   +1 more source