Results 141 to 150 of about 41,565 (267)
ABSTRACT Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system characterized by cumulative neurological disability over time. Median survival from symptom onset in large cohort studies is approximately four decades, although substantially prolonged disease courses are uncommon.
Masoud Etemadifar +4 more
wiley +1 more source
Metastatic Unfunctional Pancreatic Neuroendocrine Tumor in Lynch Syndrome
ABSTRACT Lynch syndrome (LS), a well‐known cancer risk syndrome, is caused by deleterious germline mutations in the mismatch repair genes. LS predispose patients to various types of cancers including colon adenocarcinoma. We discuss the case of a woman with LS who also developed a non‐functioning pancreatic neuroendocrine tumor (P‐NET) following ...
Fateme Salemi +5 more
wiley +1 more source
ABSTRACT Background and Aims Multiple sclerosis (MS) is a chronic inflammatory disease influenced by genetic and environmental factors. Dietary habits, reproductive characteristics, and physical activity have been proposed as potential contributors to MS susceptibility.
Nazanin Razazian +7 more
wiley +1 more source
Is it time to target no evident disease activity (NEDA) in multiple sclerosis? [PDF]
Marta, M +5 more
core +1 more source
Comorbidity may impact use of disease-modifying therapies (DMTs) among individuals with relapsing remitting multiple sclerosis (RRMS). Our objectives were to characterize the relationship between comorbidity and (1) persistence to initial DMT, (2) choice
Parks, Natalie
core
Trasplante autólogo de progenitores hematopoyéticos como opción terapéutica en la esclerosis múltiple [PDF]
[spa] INTRODUCCIÓN: La esclerosis múltiple (EM) es una enfermedad autoinmune mediada por células CD4+ autorreactivas frente a antígenos mielínicos severamente discapacitante que afecta fundamentalmente a una población joven y para la que no se dispone de
Blanco Morgado, Yolanda
core
Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu +8 more
wiley +1 more source
Cristina Guarnera, Placido Bramanti, Emanuela Mazzon IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy Abstract: In the therapeutic scenario of disease-modifying therapies for relapsing–remitting multiple sclerosis, the ...
Guarnera C, Bramanti P, Mazzon E
doaj
Introduction: Reduced quality of life (QoL) is an early feature of multiple sclerosis (MS). The effect of progression independent of relapse activity (PIRA) on QoL is poorly investigated.
Sandgren, Sofia, +5 more
core +1 more source
STAIR‐UTE, STAIR‐STE, and MT‐derived myelin biomarkers (MPF, MWF, MMF, MTR) strongly correlate in WM, gray matter, and MS lesions. All distinguish normal from abnormal tissue, though subtle differences suggest complementary information. Histological validation is needed to confirm specificity.
James Lo +7 more
wiley +1 more source

