Results 91 to 100 of about 237,874 (311)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Factors affecting entrepreneurial intention levels [PDF]

Entrepreneurship is becoming a very relevant instrument to promote economic growth and development in different regional and national economies.
Francisco Liñán, Juan Carlos Rodríguez-Cohard, José Manuel Rueda-Cantuche   +2 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Working Overtime and Turnover Intention Among Chinese Social Workers: Roles of Organizational Identity and Individual Income

SAGE Open
Although the negative effects of employee overtime have received academic attention, the relationship between overtime work and social workers’ turnover intention and its underlying mechanisms have been less studied.
Weidong Huo, Bolin Shi
doaj   +1 more source

The impact of supplementary narrative-based information on colorectal cancer screening beliefs and intention [PDF]

, 2015
Background: The potential benefits of colorectal cancer screening are limited by low uptake. This study tested whether providing narrative accounts of the colorectal cancer (CRC) screening experience positively affected beliefs about CRC screening and ...
McGregor, Lesley M, von Wagner, Christian, Raine, Rosalind, Wing Chee Yuen, von Wagner, C, Raine, R, Christian von Wagner, Robb, Kathryn A, Vart, Gemma, McGregor, LM, Kathryn A Robb, Robb, KA, Robb, Kathryn A., Jane Wardle, Wardle, Jane, Lesley M McGregor, McGregor, Lesley M., Rosalind Raine, Yuen, WC, Yuen, Wing Chee, Gemma Vart, Wardle, J, Vart, G   +22 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Desire and Behavioral Intention in Sharing Accommodation: Hedonic and Economic Benefits as Mediators and Perceived Risk and Materialism as Moderators

Tourism and Hospitality
The present study aims to explore the factors that warrant consumers’ behavioral intention through sharing accommodation. A multilayered conceptual model is developed to analyze the impact of desire on behavioral intention through hedonic and economic ...
Pooja Goel, Satyanarayana Parayitam
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Measuring Push, Pull And Personal Factors Affecting Turnover Intention: A Case Of University Teachers In Pakistan [PDF]

It has been observed that professional and qualified teacher’s retention become a challenge for Higher Education Institutions (HEIs) in Pakistan as the turnover rate has been significantly increased in recent years. The main objective of this paper is to
Iqtidar ALI SHAH, Khalid ZAMAN, Zainab FAKHR, M. Shakil AHMAD   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source