Results 91 to 100 of about 6,056,278 (299)
The development of generative AI has disrupted various fields, and the field of online healthcare is no exception. However, there is a lack of research on patients’ intention to adopt generative AI on online healthcare platforms.
Yu Li, Tian Shen, Shuyi Yang, Xi Chen
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Although the negative effects of employee overtime have received academic attention, the relationship between overtime work and social workers’ turnover intention and its underlying mechanisms have been less studied.
Weidong Huo, Bolin Shi
doaj +1 more source
The present study aims to explore the factors that warrant consumers’ behavioral intention through sharing accommodation. A multilayered conceptual model is developed to analyze the impact of desire on behavioral intention through hedonic and economic ...
Pooja Goel, Satyanarayana Parayitam
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Factors affecting entrepreneurial intention levels [PDF]
Entrepreneurship is becoming a very relevant instrument to promote economic growth and development in different regional and national economies.
Francisco Liñán +2 more
core
This study assessed the changed knowledge sharing system and innovative intention towards continuous quality improvement in one university system in the Philippines.
Niño Philip L. Perculeza
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source

