Results 241 to 250 of about 740,069 (270)

Relative dose intensity of FEC100: An analysis of outcomes

Journal of Clinical Oncology, 2005
773 Background: Adjuvant FEC100 is considered to be highly effective at improving disease-free survival (DFS) and overall survival (OS) in patients (pts) with early breast cancer (EBC). Correlation between relative dose intensity (RDI) and outcomes of adjuvant therapy is primarily based on CMF data from Bonadonna (1981).
S. Hopkins, G. Nicholas, S. Verma, S. Dent, S. Gertler   +4 more
openaire   +1 more source

Relative dose intensity (RDI) assessment in an academic center.

Journal of Clinical Oncology, 2011
139 Background: Patients with early breast cancer treated in the adjuvant setting realize maximum benefit as to disease- free and overall survival when they receive their full planned dose of chemotherapy. Due to the aggressive treatment regimens, patients are at increased risk of dose delays and reductions, which result in reduced RDI.
A. Arnaout, H. Leblebjian, S. Bartel, M. J. Hassett   +3 more
openaire   +1 more source

Relative Dose Intensity: Improving Cancer Treatment and Outcomes

Oncology Nursing Forum, 2005
To determine the incidence of and reasons for chemotherapy dose delays or reductions.A performance improvement initiative formed the basis for a prospective nursing research study.A single institution in western Pennsylvania.204 patients scheduled for nonmyeloablative chemo-therapy.Data collection forms were completed by RNs and evaluated by an ...
openaire   +2 more sources

Adjuvant chemotherapy for breast cancer – prognostic impact of relative dose-intensity.

Cancer Research, 2009
Abstract Abstract #4109 Introduction: Maintenance of adequate dose intensity (DI) is an important aim in the use of adjuvant chemotherapy for early breast cancer. Some studies report a decreased survival, if the DI is below 80% of the planned dose.
S Kahlert, J Rosenfeld, K Mair, Y Sorokina, J Engel, K Friese   +5 more
openaire   +1 more source

[Relative dose intensity of FOLFOX4 regimen].

Gan to kagaku ryoho. Cancer & chemotherapy, 2008
Oxaliplatin (L-OHP) is one of the key drugs against advanced, recurrent colorectal cancer, and FOLFOX4 regimen combination of l-leucovorin (l-LV)and 5-fluorouracil (5-FU)with oxaliplatin is a standard therapy in colorectal cancer. We performed a retrospective study that researched adverse events and relative dose intensity(RDI)to evaluate safety and ...
Daigo, Shouji, Satoshi, Matsusaka, Chie, Watanabe, Mitsukuni, Suenaga, Eiji, Shinozaki, Masanori, Matsuda, Kiyotoshi, Kuboki, Mariko, Ogura, Takashi, Ichimura, Chin, Keisho, Nobuyuki, Mizunuma, Kiyohiko, Hatake   +11 more
openaire   +1 more source

Absolute versus relative intensity of physical activity in a dose-response context

Medicine and Science in Sports and Exercise, 2001
To examine the importance of relative versus absolute intensities of physical activity in the context of population health.A standard computer-search of the literature was supplemented by review of extensive personal files.Consensus reports (Category D Evidence) have commonly recommended moderate rather than hard physical activity in the context of ...
openaire   +2 more sources

FOLFOX4 relative dose intensity and factors associated with dose reduction or stop: A cohort study.

Journal of Clinical Oncology, 2011
e19668 Background: Randomized controlled trials suggest similar efficacy and tolerance of chemotherapy in elderly cancer patients compared to younger.
F. Canoui-Poitrine, M. Laurent, E. Paillaud, P. Caillet, M. Verlinde-Carvalho, N. Reynald, T. Vesval, A. Le Thuaut, S. Bastuji-Garin, S. Culine   +9 more
openaire   +1 more source

Optimal dose reduction of FOLFIRINOX for preserving tumour response in advanced pancreatic cancer: Using cumulative relative dose intensity

European Journal of Cancer, 2017
FOLFIRINOX has increased efficacy but also toxicity. Despite various modified FOLFIRINOX regimens, how much reduction is acceptable remains unclear. This study aimed to find the optimal relative dose intensity (RDI, %) of FOLFIRINOX that preserves tumour responses in patients with advanced pancreatic cancer (PC).We reviewed 201 patients with PC treated
Jong-Chan, Lee, Jin Won, Kim, Soyeon, Ahn, Hyoung Woo, Kim, Jongchan, Lee, Young Hoon, Kim, Kyu-Hyun, Paik, Jaihwan, Kim, Jin-Hyeok, Hwang   +8 more
openaire   +2 more sources

Impact of Primary Pegfilgrastim Prophylaxis on Relative Dose Intensity in Neoadjuvant/Adjuvant FEC-100 Chemotherapy

Anticancer Research, 2020
This study aimed was to clarify the impact of pegfilgrastim (PEG) 3.6 mg primary prophylaxis of febrile neutropenia (FN) on the average relative dose intensity (ARDI) of neoadjuvant/adjuvant FEC-100 for breast cancer.This retrospective, single-centre cohort study including 296 patients who received FEC-100 compared PEG and non-PEG groups. The PEG group
Takashi, Yokokawa, Kenichi, Suzuki, Takahito, Sugisaki, Kazuo, Kobayashi, Daigo, Shouji, Hiroshi, Watanabe, Kazuyoshi, Kawakami, Tomomi, Takiguchi, Takeshi, Aoyama, Kokoro, Kobayashi, Shunji, Takahashi, Yoshinori, Ito, Shinji, Ohno, Toshihiro, Hama   +13 more
openaire   +2 more sources

[Dose intensity in cancer chemotherapy: definition, average relative dose intensity and effective dose intensity].

Bulletin du cancer, 1995
The cytotoxic activity of cancer chemotherapy is related to the dose and to the amount of drug delivered per time unit. The significance of time in the effectiveness of a treatment program is frequently overlooked. The term of dose intensity (DI) is used to define the drug dose delivered per time unit and is expressed as mg/m2 per week.
openaire   +1 more source