Results 21 to 30 of about 413,985 (241)

The influence of adjuvant chemotherapy dose intensity on overall survival in resected colon cancer: a multicentered retrospective analysis

BMC Cancer, 2022
Background Colorectal cancer remains the second leading cause of cancer death in North America. Fluorouracil and oxaliplatin based adjuvant chemotherapy for resected colon cancer (CC) reduces cancer recurrence, but also causes significant toxicity ...
Daniel Breadner, Jonathan M. Loree, Winson Y. Cheung, Meghan Gipson, Suganija Lakkunarajah, Karen E. Mulder, Jennifer L. Spartlin, Shiying Kong, Philip Q. Ding, Sharlene Gill, Stephen A. Welch   +10 more
doaj   +1 more source

The significance of relative dose intensity in adjuvant chemotherapy of pancreatic ductal adenocarcinoma-including the analysis of clinicopathological factors influencing relative dose intensity. [PDF]

Medicine (Baltimore), 2016
Recently, it has been reported that the relative dose intensity (RDI) of adjuvant chemotherapy (AC) influences survival in various cancers, but there are very few reports about RDI in pancreatic ductal adenocarcinoma (PDAC). The optimal timing for initiation of AC for PDAC also remains unknown.
Yabusaki N, Fujii T, Yamada S, Murotani K, Sugimoto H, Kanda M, Nakayama G, Koike M, Fujiwara M, Kodera Y.   +9 more
europepmc   +3 more sources

Pegfilgrastim Maintains Relative Dose Intensity and Decreases Hospitalisations in Patients With Endometrial Cancer. [PDF]

In Vivo, 2020
Data are limited regarding the use of pegfilgrastim in gynaecologic oncology. We evaluated its efficacy for maintaining dose intensity during chemotherapy.We retrospectively examined the data of 65 women (26 pegfilgrastim users) who underwent primary surgical treatment for stages IB-IV endometrial cancer and had adjuvant chemotherapy containing ...
Chikazawa K, Imai K, Ito T, Kimura A, Hiroyoshi KO, Miho Y, Kuwata T, Konno R.   +7 more
europepmc   +4 more sources

Therapeutic efficacy of dose-reduced adjuvant chemotherapy with S-1 in patients with pancreatic cancer: a retrospective study

BMC Cancer, 2022
Background S-1 adjuvant chemotherapy is the standard treatment in Asia for resectable pancreatic ductal adenocarcinoma. The relative dose intensity of adjuvant chemotherapy influences survival in pancreatic cancer but does not precisely reflect treatment
Kazuki Kobayashi, Takahiro Einama, Yasuhiro Takihata, Naoto Yonamine, Ibuki Fujinuma, Takazumi Tsunenari, Keita Kouzu, Akiko Nakazawa, Toshimitsu Iwasaki, Hideki Ueno, Yoji Kishi   +10 more
doaj   +1 more source

Safety and Relative Dose Intensity of Dose-dense Doxorubicin and Cyclophosphamide Followed by Dose-dense Paclitaxel [PDF]

Anticancer Research, 2019
Dose-dense doxorubicin and cyclophosphamide (ddAC) followed by dose-dense paclitaxel (ddP) (ddAC-P) has improved disease-free survival of patients with breast cancer. The aim of this study was to evaluate the safety and relative dose intensity (RDI) of ddAC-P administered together with pegfilgrastim.Between May 2015 and Aug 2017, 44 patients were ...
Meiko, Nishimura, Takuma, Onoe, Hideki, Sakai, Minori, Arase, Sayuri, Watanabe, Misao, Soyama, Kazuki, Hashimoto, Mayuko, Miki, Kaori, Tane, Koichi, Hirokaga, Shintaro, Takao, Koji, Matsumoto   +11 more
openaire   +2 more sources

Dose intensity analysis of high-dose carboplatin in refractory ovarian carcinoma relative to age [PDF]

Cancer, 2010
Cisplatin and carboplatin are essential to management of advanced-stage epithelial ovarian carcinoma. No published data exist regarding carboplatin dose intensity importance in ovarian cancer, nor are there data for the effect of age on the ability to deliver dose-intensive carboplatin.Retrospective dose intensity analyses were performed for 93 ...
T L, Cornelison, E, Reed
openaire   +2 more sources

The survival impact of palliative chemotherapy dose modifications on metastatic colon cancer

BMC Cancer, 2022
Background An uninterrupted dose of oxaliplatin-based cytotoxic therapy is an essential component in the standard treatment regimen of metastatic colon cancer (mCC). Data on the impacts of dose intensity reduction on the palliative treatment for patients
Mohd Naqib Zainal Abidin, Marhanis Salihah Omar, Farida Islahudin, Noraida Mohamed Shah   +3 more
doaj   +1 more source

Nutritional status predicts adjuvant chemotherapy outcomes for stage III colorectal cancer

Journal of the Anus, Rectum and Colon, 2019
Objectives: Previously, adjuvant chemotherapy using oxaliplatin was a standard treatment for patients with node-positive colorectal cancer (CRC) who underwent curative surgery. The factor predicting adverse events and therapeutic effect have not yet been
Keisuke Ihara, Satoru Yamaguchi, Yosuke Shida, Junki Fujita, Shotaro Matsudera, Maiko Kikuchi, Hiroto Muroi, Masanobu Nakajima, Kinro Sasaki, Takashi Tsuchioka, Kazuyuki Kojima   +10 more
doaj   +1 more source

Postoperative chemotherapy relative dose intensity and overall survival in patients with colon cancer. [PDF]

Cancer Chemother Pharmacol
Quantifying the association of chemotherapy relative dose intensity (RDI) with overall survival may enable supportive care interventions that improve chemotherapy RDI to estimate their magnitude of potential clinical benefit.This cohort study included 533 patients with stage II-III colon cancer who initiated a planned regimen of 12 cycles of 5 ...
Brown JC, Meyerhardt JA, Yang S, Caan BJ.   +3 more
europepmc   +3 more sources

Exercise during chemotherapy: Friend or foe?

Cancer Medicine, 2023
Background A higher chemotherapy completion rate is associated with better outcomes including treatment efficacy and overall survival. Exercise may have the potential to improve relative dose intensity (RDI) by reducing the frequency and severity of ...
Melanie Potiaumpai, Erica A. Schleicher, Ming Wang, Kristin L. Campbell, Kathleen Sturgeon, Kathryn H. Schmitz   +5 more
doaj   +1 more source