Results 41 to 50 of about 303,733 (238)

Female Mice Are Protected from Metabolic Decline Associated with Lack of Skeletal Muscle HuR

Biology, 2021
Male mice lacking HuR in skeletal muscle (HuRm−/−) have been shown to have decreased gastrocnemius lipid oxidation and increased adiposity and insulin resistance. The same consequences have not been documented in female HuRm−/− mice. Here we examine this
Allison C. Stone, Robert C. Noland, Randall L. Mynatt, Samuel E. Velasquez, David S. Bayless, Eric Ravussin, Jaycob D. Warfel   +6 more
doaj   +1 more source

Associations of relative fat mass and BMI with all‐cause mortality: Confounding effect of muscle mass

Obesity
AbstractObjectiveThe study objective was to examine associations of relative fat mass (RFM) and BMI with all‐cause mortality in the Dutch general population and to investigate whether additional adjustment for muscle mass strengthened these associations.MethodsA total of 8433 community‐dwelling adults from the PREVEND general population cohort (1997 ...
Suthahar, Navin, Zwartkruis, Victor, Geelhoed, Bastiaan, Withaar, Coenraad, Meems, Laura M. G., Bakker, Stephan J. L., Gansevoort, Ron T., van Veldhuisen, Dirk Jan, Rienstra, Michiel, de Boer, Rudolf A.   +9 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Gender and Age – Dependent effect of type 1 diabetes on obesity and altered body composition in young adults

Annals of Agricultural and Environmental Medicine, 2015
[b]Introduction and objective[/b]. The aim of the study was to evaluate the influence of age and gender on the prevalence of overweight and obesity, body composition and fatty tissue distribution in young adults with type 1 diabetes.
Agnieszka Szadkowska, Anna Madej, Katarzyna Ziółkowska, Małgorzata Szymańska, Krzysztof Jeziorny, Beata Mianowska, Iwona Pietrzak   +6 more
doaj   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Growth patterns in childhood and adolescence and adult body composition: a pooled analysis of birth cohort studies from five low and middle-income countries (COHORTS collaboration)

BMJ Open, 2023
Objective We examined associations among serial measures of linear growth and relative weight with adult body composition.Design Secondary data analysis of prospective birth cohort studies.Settings Six birth cohorts from Brazil, Guatemala, India, the ...
Shane A Norris, Aryeh D Stein, Fernando C Wehrmeister, Natália Peixoto Lima, Ana Maria Baptista Menezes, Bernardo Lessa Horta, Harshpal Sachdev, María F Kroker-Lobos, Manuel Ramírez-Zea, Shivani A Patel, Linda M Richter, Santosh K Bhargava, Linda S Adair, Reynaldo Martorell, Natalia E Poveda, Sonny A Bechayda, Delia B Carba, Mónica Mazariegos, Lukhanyo H Nyati   +18 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Association Research between Relative Fat Mass and the Incidence Risk of Cardiometabolic Multimorbidity [PDF]

Zhongguo quanke yixue
Background Cardiometabolic multimorbidity (CMM) represents one of the most prevalent and stable multimorbidity patterns. Relative fat mass (RFM), as a novel anthropometric indicator for assessing adiposity, has shown promise as a predictor of individual ...
GU Handong, LU Hongrun, GU Keyi, HAN Zheng, YANG Fei, FU Xiaoya, WANG Weiqiang
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source