Results 51 to 60 of about 6,367,878 (242)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Dietary fat intake and obesity : an empirical study in Greek adults. [PDF]

The empirical evidence concerning the associations between diet, particularly fat intake, and obesity is inconclusive. The aim of the present study was to investigate cross-sectional associations between general and central ...
Lagiou, Areti
core   +1 more source

Genetic markers of obesity risk: stronger associations with body composition in overweight compared to normal-weight children. [PDF]

, 2011
Genetic factors are important determinants of overweight. We examined whether there are differential effect sizes depending on children's body composition.
Kries, Rüdiger von, Andrew R. Ness, Rüdiger von Kries, von Kries Rüdiger, Ong Ken K., Ong, Ken K., Beyerlein, Andreas, Andreas Beyerlein, Andrew R Ness, Ong Ken, K, Ken K. Ong, Ness, Andrew R., Ken K Ong, Bayerlain, Andreas, Beyerlein Andreas, Ness Andrew R., Von Kries, Rudiger, Ness, A   +17 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Growth patterns in childhood and adolescence and adult body composition: a pooled analysis of birth cohort studies from five low and middle-income countries (COHORTS collaboration)

BMJ Open, 2023
Objective We examined associations among serial measures of linear growth and relative weight with adult body composition.Design Secondary data analysis of prospective birth cohort studies.Settings Six birth cohorts from Brazil, Guatemala, India, the ...
Shane A Norris, Aryeh D Stein, Fernando C Wehrmeister, Natália Peixoto Lima, Ana Maria Baptista Menezes, Bernardo Lessa Horta, Harshpal Sachdev, María F Kroker-Lobos, Manuel Ramírez-Zea, Shivani A Patel, Linda M Richter, Santosh K Bhargava, Linda S Adair, Reynaldo Martorell, Natalia E Poveda, Sonny A Bechayda, Delia B Carba, Mónica Mazariegos, Lukhanyo H Nyati   +18 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Fat Mass and Obesity-Associated Gene (FTO) in Eating Disorders: Evidence for Association of the rs9939609 Obesity Risk Allele with Bulimia nervosa and Anorexia nervosa [PDF]

, 2012
Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating ...
Wichmann, Heinz-Erich, Herzog, Wolfgang, Estivill, X., Fichter, Manfred, Sorbi, S., Ribasés Haro, Marta, Herpertz-Dahlmann, B., Hebebrand, J., Ehrlich, Stefan, Greene, B. H., Müller, Timo D., Estivill, Xavier, Fernandez-Aranda, Fernando, Scherag, Susan, Cavallini, M. C., Hebebrand, Johannes, Schäfer, Helmut, Ribases, Marta, Sorbi, Sandro, Herpertz Dahlmann, Beate, Lehmkuhl, Ulrike, Grallert, Harald, Fleischhaker, C., Wichmann, H.-E., Illig, T., Bellodi, L., Herzog, W., Fichter, M., Cellini, E., Bellodi, Laura, Ricca, Valdo, Fleischhaker, Christian, Scherag, Susann, Di Bella, D., Bella, Daniela Di, Cavallini, M.C., Scherag, S., Nacmias, Benedetta, Greene, B.H., Illig, Thomas, Schäfer, H., Fernández Aranda, Fernando, Fernández-Aranda, F., Di Bella, Daniela, Gratacòs, Monica, Erzegovesi, S., Cellini, Elena, Scherag, Andre, Fichter, Manfred M., Greene, Brandon H., Müller, T. D., Grallert, H., Nacmias, B., Hinney, A., Hinney, Anke, Erzegovesi, Stefano, Ribasés, M., Scherag, A., Wichmann, H. E., Müller, T.D., Cavallini, Maria C., Herpertz-Dahlmann, Beate, Estivill, Xavier, 1955-, Gratacòs, M., Ricca, V., Ehrlich, S., Lehmkuhl, U., Wichmann, H.-Erich   +67 more
core   +1 more source

Association Research between Relative Fat Mass and the Incidence Risk of Cardiometabolic Multimorbidity [PDF]

Zhongguo quanke yixue
Background Cardiometabolic multimorbidity (CMM) represents one of the most prevalent and stable multimorbidity patterns. Relative fat mass (RFM), as a novel anthropometric indicator for assessing adiposity, has shown promise as a predictor of individual ...
GU Handong, LU Hongrun, GU Keyi, HAN Zheng, YANG Fei, FU Xiaoya, WANG Weiqiang
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Associations between diet, physical activity and body fat distribution: a cross sectional study in an Indian population. [PDF]

, 2015
BACKGROUND: Obesity is a growing health problem in India and worldwide, due to changes in lifestyle. This study aimed to explore the independent associations between dietary and physical activity exposure variables and total body fat and distribution in ...
Krishna, K V Radha, Sullivan, Ruth, Krishna, KV Radha, Kuper, Hannah, Wells, Jonathan, Taylor, Amy E, Bowen, Liza, Ekelund, Ulf, Kulkarni, Bharati, Wells, Jonathan CK, Kinra, Sanjay, Ben-Shlomo, Yoav, Ebrahim, Shah, Radha Krishna, K. V., Taylor, Amy E.   +14 more
core   +1 more source