Results 71 to 80 of about 667,927 (279)

Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice [PDF]

, 2012
<p>Background: Dietary restriction (DR) extends lifespan and induces beneficial metabolic effects in many animals. What is far less clear is whether animals retain a metabolic memory to previous DR exposure, that is, can early-life DR preserve ...
A Ceriello, A Dubey, A Nakamura, A Taguchi, BJ Merry, BJ Merry, BP Yu, BS Hass, C Hambly, C Messier, C Selman, C Selman, CK Lee, CK Lee, DP Argentino, EP Weiss, F Capstick, H Maeda, J Cantley, J Jacobson, JD Mulligan, JF Clinthorne, JM Dhahbi, JM Dhahbi, JR Mitchell, JR Speakman, L Fontana, LK Heilbronn, LM Redman, MJ Forster, MJ Forster, R Weindruch, R Weindruch, RJ Colman, RM Anson, S Goto, S Hempenstall, S Keipert, S Park, S Rezzi, SK Barnes, SL Johnston, SS Jessani, SX Cao, TM Wallace, W Mair, X Li   +46 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Growth patterns in childhood and adolescence and adult body composition: a pooled analysis of birth cohort studies from five low and middle-income countries (COHORTS collaboration)

BMJ Open, 2023
Objective We examined associations among serial measures of linear growth and relative weight with adult body composition.Design Secondary data analysis of prospective birth cohort studies.Settings Six birth cohorts from Brazil, Guatemala, India, the ...
Shane A Norris, Aryeh D Stein, Fernando C Wehrmeister, Natália Peixoto Lima, Ana Maria Baptista Menezes, Bernardo Lessa Horta, Harshpal Sachdev, María F Kroker-Lobos, Manuel Ramírez-Zea, Shivani A Patel, Linda M Richter, Santosh K Bhargava, Linda S Adair, Reynaldo Martorell, Natalia E Poveda, Sonny A Bechayda, Delia B Carba, Mónica Mazariegos, Lukhanyo H Nyati   +18 more
doaj   +1 more source

Air Displacement Plethysmography and Resistance Exercise [PDF]

, 2015
Purpose: The purpose of this study was to examine the effect of resistance exercise (RE) on body composition using air-displacement plethysmography (ADP) within 2 hours of completing RE.
Deitrick, Ronald W., Grossman, Joan Cebrick   +1 more
core   +2 more sources

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice [PDF]

, 2012
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease).
Alex J. Harper, Alison D. McNeilly, Almind, Arch, Azzu, Balleza-Tapia, Biessels, Burcelin, Butler, Cai, Cannon, Choi, Cioffi, Cole, Craft, Craft, D. Lee Hamilton, David R. Howlett, De Felice, de la Monte, de la Monte, Dominguez, Folch, Fromme, Frölich, Fukumoto, Harrison, Hassing, Ho, Huse, Ishrut Hussain, Janson, Jennifer Gallagher, John R. Speakman, Judy Latcham, Kirsten A. Bannon, Kobayashi, Kontani, Kus, LaFerla, Laura A. Burgess, Lee, Li, Lobke M. Vaanholt, Luchsinger, Luo, Mensink, Michael L.J. Ashford, Mirshamsi, Paul J. Meakin, Pietrak, Rapoport, Rivera, Roberds, Sankaranarayanan, Selman, Speakman, Steen, Tiraby, Vassar, Vassar, Vattemi, Xie   +62 more
core   +4 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Reduced sleep duration affects body composition, dietary intake and quality of life in obese subjects. [PDF]

, 2016
Purpose Sleep duration has emerged as a crucial factor affecting body weight and feeding behaviour. The aim of our study was to explore the relationship among sleep duration, body composition, dietary intake, and quality of life (QoL) in obese ...
DI LAZZARO, Luca, Donini, Lorenzo Maria, Federica, Luisi, Giampaolo, Polidoro, Gnessi, Lucio, Lenzi, Andrea, Lubrano, Carla, Mariani, Stefania, Marocco, Chiara, Merola, Gianluca, Poggiogalle, Eleonora, Silvia, Migliaccio   +11 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Plasma metabolites reflect seasonally changing metabolic processes in a long-distance migrant shorebird (Calidris canutus) [PDF]

, 2002
Migrant birds have tightly scheduled annual cycles consisting of several distinct life cycle (sub-)stages such as reproduction, migration, moult and overwintering, each of which have specific metabolic requirements (e.g., fattening during migration ...
Jenni, Lukas,, Jenni-Eiermann, Susanne,, Piersma, Theunis,   +2 more
core   +2 more sources

Associations of relative fat mass and BMI with all‐cause mortality: Confounding effect of muscle mass

Obesity
AbstractObjectiveThe study objective was to examine associations of relative fat mass (RFM) and BMI with all‐cause mortality in the Dutch general population and to investigate whether additional adjustment for muscle mass strengthened these associations.MethodsA total of 8433 community‐dwelling adults from the PREVEND general population cohort (1997 ...
Suthahar, Navin, Zwartkruis, Victor, Geelhoed, Bastiaan, Withaar, Coenraad, Meems, Laura M. G., Bakker, Stephan J. L., Gansevoort, Ron T., van Veldhuisen, Dirk Jan, Rienstra, Michiel, de Boer, Rudolf A.   +9 more
openaire   +3 more sources