Results 101 to 110 of about 6,752 (264)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Einstein, Gödel, Heidegger. Some observations about the concept of time
Pensamiento. Revista de Investigación e Información Filosófica, 2013 In this article we focus on some of the paths which help us to understand the philosophical question of time. The interpretative frame is composed of Einstein’s theory of relativity, against which we have the observations of Gödel and Heidegger on this ...
Diego Malquori
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
An Extreme Rotating Black Hole in New Massive Gravity Theory
Revista Politécnica, 2017 New Massive Gravity is an alternative theory to General Relativity that is used to describe the gravitational field in a (2+1)-dimensional spacetime. Black hole solutions have been found in this theory, in particular an asymptotically anti-de Sitter ...
Mario Llerena +2 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Can Lorentz transformations be determined by the null Michelson-Morley result?
Revista Brasileira de Ensino de FísicaThe so-called principle of relativity is able to fix a general coordinate transformation which differs from the standard Lorentzian form only by an unknown speed which cannot in principle be identified with the light speed.
J. A. S. Lima, Fernando D. Sasse
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L’essenza fenomenologica della relatività. Questioni di confine tra Husserl e Einstein [PDF]
S&F_scienzaefilosofia.it, 2016 The phenomenological Essence of Relativity. Matters concerning the Border between Husserl and Einstein According to Hermann Weyl, Einstein’s Relativity Theory is a method that combines “analysis of essence” and “mathematical construction”.
Giorgio Jules Mastrobisi
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The Extended Theory of Relativity
This paper combines Albert Einstein's General Theory of Relativity(in which he proposes space-time) and the second law of Thermodynamics(entropy) to propose a new cause for cosmic expansion and to provide justification for a possible beginning and end of the universe.
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Spacetime Emergence: An (In)effective Story
Philosophy of PhysicsPhysicists and philosophers are increasingly prone to regarding our current physical theories as providing ‘effective descriptions’ of real-world systems.
Mike D. Schneider
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