Results 141 to 150 of about 5,408,284 (306)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Gravitational radiation of a spherically symmetric source in f(R)-gravitation

open access: yesEuropean Physical Journal C: Particles and Fields
It is shown that Birkhoff’s theorem for the general theory of relativity is overcome in the f(R)-theory of gravitation. That means, the f(R)-theory of gravitation, unlike Einstein’s general theory of relativity, does not forbid gravitational radiation ...
Pham Van Ky   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

What can we Learn about the Ontology of Space and Time from the Theory of Relativity [PDF]

open access: yes, 2012
This chapter presents an opinionated assessment of what we can learn about the ontology of space and time from the special and general theories of relativity.
Norton, John D.
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

'No Success like Failure ...': Einstein's Quest for General Relativity, 1907-1920 [PDF]

open access: yes, 2008
This is the chapter on general relativity for the Cambridge Companion to Einstein which I am co-editing with Christoph ...
Janssen, Michel
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Informal Teaching of Special Theory of Relativity

open access: yesScientia in Educatione, 2017
In the present Case Study we explore the comprehension levels of relativity theory in prospective science teachers who take the introduction to physics lesson at the Faculty of Education.
Jindřiška Svobodová   +2 more
doaj   +2 more sources

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