Results 131 to 140 of about 5,408,284 (306)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The Eclipse to Confirm the General Theory of Relativity [PDF]
, 2015 One of the milestones of the science of light commemorated during this International Year of Light and Light-based Technologies is “the embedding of light in cosmology through general relativity in 1915,” that is, the celebration of the centenary of ...
Beléndez, Augusto +1 more
core +1 more source
Einstein, Gödel, Heidegger. Some observations about the concept of time
Pensamiento. Revista de Investigación e Información Filosófica, 2013 In this article we focus on some of the paths which help us to understand the philosophical question of time. The interpretative frame is composed of Einstein’s theory of relativity, against which we have the observations of Gödel and Heidegger on this ...
Diego Malquori
doaj
Can Lorentz transformations be determined by the null Michelson-Morley result?
Revista Brasileira de Ensino de FísicaThe so-called principle of relativity is able to fix a general coordinate transformation which differs from the standard Lorentzian form only by an unknown speed which cannot in principle be identified with the light speed.
J. A. S. Lima, Fernando D. Sasse
doaj +1 more source
L’essenza fenomenologica della relatività. Questioni di confine tra Husserl e Einstein [PDF]
S&F_scienzaefilosofia.it, 2016 The phenomenological Essence of Relativity. Matters concerning the Border between Husserl and Einstein According to Hermann Weyl, Einstein’s Relativity Theory is a method that combines “analysis of essence” and “mathematical construction”.
Giorgio Jules Mastrobisi
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
An Extreme Rotating Black Hole in New Massive Gravity Theory
Revista Politécnica, 2017 New Massive Gravity is an alternative theory to General Relativity that is used to describe the gravitational field in a (2+1)-dimensional spacetime. Black hole solutions have been found in this theory, in particular an asymptotically anti-de Sitter ...
Mario Llerena +2 more
doaj
Spacetime Emergence: An (In)effective Story
Philosophy of PhysicsPhysicists and philosophers are increasingly prone to regarding our current physical theories as providing ‘effective descriptions’ of real-world systems.
Mike D. Schneider
doaj +1 more source