Results 31 to 40 of about 1,633,391 (296)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

System Dynamic Behavior Modeling Based on Extended GO Methodology

open access: yesIEEE Access, 2018
The GO methodology, which is a success-oriented system analysis technique, is effective for evaluating the reliability of complex systems with multiple states and time-series. It is widely used in the domain of nuclear and ship industry.
Yi Ren   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Heuristic Hybrid Optimization Approach for Spare Parts and Maintenance Workers Under Partial Pooling

open access: yesIEEE Access, 2019
The joint planning of spare parts and maintenance workers in a multiple echelon inventory system with lateral and cross-echelon transshipment can reduce the total cost of the system.
Bowen Cui   +6 more
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

open access: yesFEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii   +8 more
wiley   +1 more source

Experimental and simulation studies of radiation‐induced single event burnout in SiC‐based power MOSFETs

open access: yesIET Power Electronics, 2021
The single event burnout (SEB) effects of SiC power MOSFET are investigated by irradiations. An SEB is observed when drain biased above 400 V for 181Ta ion irradiation.
Chao Peng   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Optimal Design of Accelerated Life Test Plan for Test Standard of a Manufacturer Making Multi-Series Products

open access: yesIEEE Access, 2019
To win fierce competition, a manufacturer would produce multi-series products to meet the diverse needs of customers. These products shall comply with the same test standard to estimate reliability before being launched into market.
Zixuan Pei, Yunxia Chen, Kunsong Lin
doaj   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

open access: yesFEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman   +3 more
wiley   +1 more source

An Integral Formulation of Two-Parameter Fatigue Crack Growth Model

open access: yesAdvances in Materials Science and Engineering, 2018
A two-parameter fatigue crack growth algorithm in integral form is proposed, which can describe the continuous crack growth process over the time period.
Jianguo Wu   +3 more
doaj   +1 more source

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