Results 61 to 70 of about 1,503,593 (314)

Skill Vehicle Routing Problem With Time Windows Considering Dynamic Service Times and Time-Skill-Dependent Costs

open access: yesIEEE Access, 2019
Service processes in modern logistic systems tend to be highly specialized and intellectualized. However, some casual and unexpected behavior may occur, causing specific dynamic interactions among their many constituents.
Xiaoyuan Yan   +5 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

Designing for Reliability

open access: yesMeasurement and Control, 1974
In the design of electronic equipment, reliability is one of many requirements, such as weight, size, cost, power input and performance which must be given adequate attention in arriving at the most effective product. Like most other characteristics, reliability is a feature which must be given due attention at all phases of the design, and cannot ...
openaire   +3 more sources

A Generative Adversarial Network-Based Intelligent Fault Diagnosis Method for Rotating Machinery Under Small Sample Size Conditions

open access: yesIEEE Access, 2019
Rotating machinery plays a key role in mechanical equipment, and the fault diagnosis of rotating machinery is a popular research topic. To overcome the dependency on expert knowledge regarding conventional time-frequency analysis diagnosis methods ...
Yu Ding   +4 more
doaj   +1 more source

Analysis of University Students’ Behavior Based on a Fusion K-Means Clustering Algorithm

open access: yesApplied Sciences, 2020
With the development of big data technology, creating the ‘Digital Campus’ is a hot issue. For an increasing amount of data, traditional data mining algorithms are not suitable. The clustering algorithm is becoming more and more important in the field of
Wenbing Chang   +6 more
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Optimization of Spare Parts Varieties Based on Stochastic DEA Model

open access: yesIEEE Access, 2018
Accurate inventory management starts with the scientific and rational classification of numerous varieties of spare parts. This paper presents a stochastic data envelopment analysis (DEA) model to address the problem of optimization of spares varieties ...
Meilin Wen   +4 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Modeling the Capacitated Multi-Level Lot-Sizing Problem under Time-Varying Environments and a Fix-and-Optimize Solution Approach

open access: yesEntropy, 2019
In this study, we investigated the time-varying capacitated lot-sizing problem under a fast-changing production environment, where production factors such as the setup costs, inventory-holding costs, production capacities, or even material prices may be ...
Meng You   +5 more
doaj   +1 more source

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