Results 71 to 80 of about 1,633,391 (296)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A Generative Adversarial Network-Based Intelligent Fault Diagnosis Method for Rotating Machinery Under Small Sample Size Conditions

IEEE Access, 2019
Rotating machinery plays a key role in mechanical equipment, and the fault diagnosis of rotating machinery is a popular research topic. To overcome the dependency on expert knowledge regarding conventional time-frequency analysis diagnosis methods ...
Yu Ding, Liang Ma, Jian Ma, Chao Wang, Chen Lu   +4 more
doaj   +1 more source

Reliability Assessment and Screening by Reliability IndicatorMethods [PDF]

Active and Passive Electronic Components, 1983
Built‐in flaws in electronic components have been recognized as a serious cause of failure. They are difficult to screen away by conventional methods because the times‐to‐failures for component working in systems are often rather long and because accelerated burn‐in may screen by the wrong failure mechanisms. As an alternative, the concept and possible
openaire   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Optimization of Spare Parts Varieties Based on Stochastic DEA Model

IEEE Access, 2018
Accurate inventory management starts with the scientific and rational classification of numerous varieties of spare parts. This paper presents a stochastic data envelopment analysis (DEA) model to address the problem of optimization of spares varieties ...
Meilin Wen, Tianpei Zu, Miaomiao Guo, Rui Kang, Yi Yang   +4 more
doaj   +1 more source

Test-Retest Reliability of Functional Connectivity in Adolescents With Depression [PDF]

, 2023
Chris Camp, Stephanie Noble, Dustin Scheinost, Argyris Stringaris, Dylan M. Nielson   +4 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Modeling the Capacitated Multi-Level Lot-Sizing Problem under Time-Varying Environments and a Fix-and-Optimize Solution Approach

Entropy, 2019
In this study, we investigated the time-varying capacitated lot-sizing problem under a fast-changing production environment, where production factors such as the setup costs, inventory-holding costs, production capacities, or even material prices may be ...
Meng You, Yiyong Xiao, Siyue Zhang, Shenghan Zhou, Pei Yang, Xing Pan   +5 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Shape-position perceptive fusion electronic skin with autonomous learning for gesture interaction

Microsystems & Nanoengineering
Wearable devices, such as data gloves and electronic skins, can perceive human instructions, behaviors and even emotions by tracking a hand's motion, with the help of knowledge learning.
Qian Wang, Mingming Li, Pingping Guo, Liang Gao, Ling Weng, Wenmei Huang   +5 more
doaj   +1 more source