Results 51 to 60 of about 1,247,116 (346)

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reliability Assessment of a Series System with Weibull-Distributed Components Based on Zero-Failure Data

open access: yesApplied Sciences
This study focuses on the reliability assessment of a series system composed of Weibull-distributed components. Because high-reliability components rarely fail during life testing or actual operation, conventional system reliability analysis methods ...
Ziang Li, Huimin Fu, Jianchao Guo
doaj   +1 more source

Modular System Modeling for Quantitative Reliability Evaluation of Technical Systems [PDF]

open access: yesModeling, Identification and Control, 2016
In modern times, it is necessary to offer reliable products to match the statutory directives concerning product liability and the high expectations of customers for durable devices. Furthermore, to maintain a high competitiveness, engineers need to know
Stephan Neumann   +4 more
doaj   +1 more source

Factor structure and construct validity of the Adult Social Care Outcomes Toolkit for Carers (ASCOT-Carer) [PDF]

open access: yes, 2015
Background: The ASCOT-Carer is a self-report instrument designed to measure social care-related quality of life (SCRQoL). This article presents the psychometric testing and validation of the ASCOT-Carer four response-level interview (INT4) in a sample of
A Bowling   +57 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Design of Control Chart in Presence of Hybrid Censoring Scheme

open access: yesIEEE Access, 2018
In this paper, a new reliability testing control chart has been developed using the hybrid censoring scheme for the Weibull distribution. The in-control and out-of-control probabilities are estimated for the desired quality characteristic using the ...
Muhammad Aslam   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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