Results 51 to 60 of about 438,848 (266)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Don’t Forget the Model in Your Model-based Reliability Coefficients: A Reply to McNeish (2018)

Collabra: Psychology, 2019
McNeish (2018) advocates that researchers abandon coefficient alpha in favor of alternative reliability measures, such as the 1-factor reliability (coefficient omega), a total reliability coefficient based on an exploratory bifactor solution (“Revelle’s ...
Victoria Savalei, Steven P. Reise
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

THE ANALYSIS OF QUALITY OF DOUGH FROM A COURSE OF THE HIGHER MATHEMATICS ON THE SUBJECT "LINEAR ALGEBRA, ANALYTICAL GEOMETRY"

Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2015
In article the mathematico-statistical analysis of quality of dough on the subject "Linear Algebra, Analytical Geometry" is carried out. Quality of dough decides on the help of such characteristics as reliability, a validity and a diskriminativnost.
Larisa V. Limanova, Lidiya Aleksandrovna Muratova   +1 more
doaj  

Chinese version and reliability and validity test of the Cancer Support Person's Unmet Needs Survey

Huli yanjiu, 2022
ObjectiveTo translate the Cancer Support Person's Unmet Needs Survey（SPUNS⁃SF23），and to test its reliability and validity.MethodsChinese version of SPUNS⁃SF23 was formed by translation and cultural adjustment.A total of 280 family caregivers of renal ...
LI Dongdong, CHEN Qingli, SUN Ting
doaj  

Standard Errors for Reliability Coefficients

Psychometrika
Abstract Reliability analysis is one of the most conducted analyses in applied psychometrics. It entails the assessment of reliability of both item scores and scale scores using coefficients that estimate the reliability (e.g., Cronbach’s alpha), measurement precision (e.g., estimated standard error of measurement), or the ...
openaire   +3 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

THE STATISTICAL ANALYSIS OF THE QUALITY OF A TEST FROM A COURSE OF HIGHER MATHEMATICS ON THE TOPIC "LIMITS. DERIVATIVES"

Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2015
In article the mathematical and statistical analysis of the quality of a test on a subject "Limits. Derivatives" is carried out. The most important characteristics at quality check of a test are reliability and validity.
Larisa V. Limanova, Lidiya A. Muratova
doaj  

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Increase of reliability of the pedagogical test "linear algebra, analytical geometry"

Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2016
Quality of pedagogical dough is estimated by means of characteristics of reliability, a validity and diskriminativnost. This article is devoted to the analysis of reliability of the processed pedagogical test "Linear Algebra, Analytical Geometry" of a ...
Larisa V. Limanova
doaj