Results 91 to 100 of about 9,948,079 (293)

Online Model-Based Remaining-Useful-Life Prognostics for Aircraft Cooling Units Using Time-Warping Degradation Clustering

, 2021
Remaining-useful-life prognostics for aircraft components are central for efficient and robust aircraft maintenance. In this paper, we propose an end-to-end approach to obtain online, model-based remaining-useful-life prognostics by learning from ...
Mitici, M.A. (author), Mihaela Mitici, de Pater, I.I. (author), Ingeborg de Pater   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Trend-Fluctuation Correlated Attention Unit for Remaining Useful Life Prediction

IEEE Access
Health indicators (HIs) are measures that consolidate complex machinery characteristics into a single dimension and have been extensively studied for predicting the remaining useful life (RUL).
Hanbyeol Park, Sunghyun Sim, Yunkyung Park, Hyerim Bae   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Remaining useful life prediction using elliptical basis function network and Markov Chain [PDF]

, 2010
This paper presents a novel method for remaining \ud useful life prediction using the Elliptical Basis Function (EBF) network and a Markov chain. The EBF structure is trained by a modified Expectation-Maximization (EM) algorithm in order to take into ...
Yu, Yi, Sun, Yong, Ma, Lin, Gu, YuanTong
core  

Novel metrics to evaluate probabilistic remaining useful life prognostics with applications to turbofan engines

, 2022
Well-established metrics such as the Root Mean Square Error or the Mean Absolute Error are not suitable to evaluate estimated distributions of the Remaining Useful Life (i.e., probabilistic prognostics). We therefore propose novel metrics to evaluate the
Mitici, M.A. (author), de Pater, I.I. (author), Ingeborg De Pater, Mihaela Mitici   +3 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Rolling Bearing Remaining Useful Life Prediction Based on CNN-VAE-MBiLSTM

Sensors
Ensuring precise prediction of the remaining useful life (RUL) for bearings in rolling machinery is crucial for preventing sudden machine failures and optimizing equipment maintenance strategies.
Lei Yang, Yibo Jiang, Kang Zeng, Tao Peng   +3 more
doaj   +1 more source