Results 81 to 90 of about 9,948,079 (293)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Differentially Private Federated Learning for Remaining Useful Life Prediction

Applied Sciences
Accurate remaining useful life (RUL) prediction is essential for the safe and cost-effective operation of safety-critical systems such as electronic components and engines.
Arturs Nikulins, Kārlis Freivalds, Ivars Namatēvs, Kaspars Sudars, Audris Arzovs, Wilhelm Söderkvist Vermelin, Madhav Mishra, Kaspars Ozols   +7 more
doaj   +1 more source

Remaining useful life prediction based on an integrated neural network

工程科学学报, 2020
Unexpected failures and unscheduled maintenance activities of mechanical systems might incur considerable waste of resources and high investment costs. Thus, in recent years, prognostics and health management (PHM) has received a lot of attention because
Yong-feng ZHANG, Zhi-qiang LU
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Remaining Useful Life Prediction Based on Deep Learning: A Survey

Sensors
Remaining useful life (RUL) is a metric of health state for essential equipment. It plays a significant role in health management. However, RUL is often random and unknown.
Fuhui Wu, Qingbo Wu, Yusong Tan, Xinghua Xu   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Reliability Prediction of TFT-LCD Modules in Harsh Environments Using Physics-Guided Machine Learning

Photonics
Accurate Remaining Useful Life (RUL) prediction of TFT-LCD modules is critical for industrial predictive maintenance, yet it remains heavily challenged by complex degradation mechanisms in different climates.
Rui Zhou, Han Li, Xiaoqin Wei, Haitao Zhu, Xu Zhou, Xiaojie Li, Rihui Yao, Wei Xu, Honglong Ning, Junbiao Peng   +9 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source