Results 81 to 90 of about 9,602,001 (284)

Remaining useful life prediction based on an integrated neural network

工程科学学报, 2020
Unexpected failures and unscheduled maintenance activities of mechanical systems might incur considerable waste of resources and high investment costs. Thus, in recent years, prognostics and health management (PHM) has received a lot of attention because
Yong-feng ZHANG, Zhi-qiang LU
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Reliability Prediction of TFT-LCD Modules in Harsh Environments Using Physics-Guided Machine Learning

Photonics
Accurate Remaining Useful Life (RUL) prediction of TFT-LCD modules is critical for industrial predictive maintenance, yet it remains heavily challenged by complex degradation mechanisms in different climates.
Rui Zhou, Han Li, Xiaoqin Wei, Haitao Zhu, Xu Zhou, Xiaojie Li, Rihui Yao, Wei Xu, Honglong Ning, Junbiao Peng   +9 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Data-Driven Machine Learning Methods for Remaining Useful Life Prediction

, 2022
I will present my work exploring machine learning solutions for remaining useful life prediction for physical devices. In my work, I predict remaining useful life for hard-disk drives and aircraft engines.
Coursey, Austin
core   +1 more source

Fuzzy Inference System-Based Prognostics for Remaining Useful Life Estimation

Egyptian Informatics Journal
Prognostics and health management (PHM) plays a critical role in ensuring the reliability and safety of complex engineering systems such as aircraft engines.
Mahmut Sami Şaşmaztürk, Ferhat Yuna
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

AI-based remaining useful life prediction of seawater desalination membranes

Chemical Engineering Journal Advances
Remaining Useful Life (RUL) of Reverse Osmosis (RO) membranes is defined as the anticipated time until the RO membrane reaches a specified performance threshold, triggering maintenance actions to enhance system longevity and efficiency.
Hussam Alshraideh, Fajer Al Ali, Mahmoud Awad, Amani Al-Othman   +3 more
doaj   +1 more source