Results 71 to 80 of about 400,124 (266)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Rolling Bearing Remaining Useful Life Prediction Based on CNN-VAE-MBiLSTM

Sensors
Ensuring precise prediction of the remaining useful life (RUL) for bearings in rolling machinery is crucial for preventing sudden machine failures and optimizing equipment maintenance strategies.
Lei Yang, Yibo Jiang, Kang Zeng, Tao Peng   +3 more
doaj   +1 more source

A Remaining Useful Life Prediction Method Considering the Dimension Optimization and the Iterative Speed

IEEE Access, 2019
Tool life prediction is critical to workpiece quality and machining costs. In this paper, a remaining useful life prediction method was proposed, which considering the dimension optimization accuracy of vibration features and the iterative speed of ...
Yiming Li, Xiangmin Meng, Zhongchao Zhang, Guiqiu Song   +3 more
doaj   +1 more source

Data-Driven Remaining Useful Life Estimation

Annual Conference of the PHM Society
This paper explores the development and application of data-driven prognostic models for estimating the Remaining Useful Life (RUL) of Nuclear Power Plant (NPP) condensers experiencing tube fouling. Due to the unavailability of run-to-failure industry sensor data, we utilized simulated data generated by the Asherah Nuclear Power Plant Simulator (ANS ...
Ark Ifeanyi, Mattia Zanotelli, Jamie Coble   +2 more
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Research on Degradation Modeling and Life Prediction Method of Lithium-Ion Battery in Dynamic Environment

IEEE Access, 2019
Lithium-ion batteries are the main form of energy providers for electric vehicles. To ensure the reliability and the safety of electric vehicles, it is necessary to estimate the remaining useful life of lithium-ion batteries.
Dongxu Shen, Tingting Xu, Lifeng Wu, Yong Guan   +3 more
doaj   +1 more source