Results 91 to 100 of about 88,886 (260)

Bayesian Networks for Remaining Useful Life Prediction

PHM Society European Conference
Remaining useful life (RUL) prediction is a critical task in the field of condition-based maintenance. It is important to perform RUL prediction in a statistical sound way. However, it is not straightforward to properly combine multiple information sources about an asset, such as available statistics, measurements, derived features, and prior knowledge
Erik Hostens, Kerem Eryilmaz, Merijn Vangilbergen, Ted Ooijevaar   +3 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A review on rail remaining useful life prediction

Transportation Safety and Environment
Abstract Rail is one of the most basic components of railway tracks. Accurate prediction of the remaining useful life of rail is important for ensuring operational safety, optimizing maintenance resource allocation and reducing operational costs. Nevertheless, research on the prediction of the remaining useful life of rail is limited,
Yuan Cao, Jian Li, Yongkui Sun, Shuai Su, Feng Wang   +4 more
openaire   +1 more source

Remaining useful life prediction of lithium-ion batteries: A decomposition-based multi-model prediction approach

AIP Advances
Accurate prediction of the Remaining Useful Life (RUL) of lithium-ion batteries is critical to ensuring the reliability and safety of battery-powered systems.
Shuyi Xue, Lei Li
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Prediction of Remaining Useful Life of Aero-engines Based on CNN-LSTM-Attention

International Journal of Computational Intelligence Systems
Accurately predicting the remaining useful life (RUL) of aircraft engines is crucial for maintaining financial stability and aviation safety. To further enhance the prediction accuracy of aircraft engine RUL, a deep learning-based RUL prediction method ...
Sizhe Deng, Jian Zhou
doaj   +1 more source

A Multi-Model Fusion Framework for Aeroengine Remaining Useful Life Prediction

Eng
As the core component of aircraft systems, aeroengines require accurate Remaining Useful Life (RUL) prediction to ensure flight safety, which serves as a key part of Prognostics and Health Management (PHM).
Bing Tan, Yang Zhang, Xia Wei, Lei Wang, Yanming Chang, Li Zhang, Yingzhe Fan, Caio Graco Rodrigues Leandro Roza   +7 more
doaj   +1 more source