Results 111 to 120 of about 59,932 (250)

Use of remdesivir in children with covid-19 infection: A quick narrative review [PDF]

, 2021
SARS-CoV-2 infection has a severe course in a small percentage of children. Remdesivir has shown promising results in reducing hospitalisation time in adults, but data on mortality rate are conflicting and few studies are available on its use use in ...
Cardinale F., Chiappini E., De Filippo M., Del Giudice M. M., Galli L., La Tessa A., Licari A., Manti S., Marseglia G. L., Motisi M. A., Tosca M.   +10 more
core   +1 more source

Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial

Canadian Medical Association Journal, 2022
Background: The role of remdesivir in the treatment of patients in hospital with COVID-19 remains ill defined in a global context. The World Health Organization Solidarity randomized controlled trial (RCT) evaluated remdesivir in patients across many ...
Karim Ali, T. Azher, M. Baqi, A. Binnie, S. Borgia, F. Carrier, Yiorgos A Cavayas, N. Chagnon, M. Cheng, J. Conly, Cecilia T. Costiniuk, P. Daley, N. Daneman, Josh Douglas, C. Downey, E. Duan, Emmanuelle Duceppe, Madeleine Durand, S. English, G. Farjou, Evradiki Fera, P. Fontela, R. Fowler, M. Fralick, Anna Geagea, J. Grant, Luke Harrison, Thomas C Havey, Holly L. Hoang, L. Kelly, Y. Keynan, K. Khwaja, G. Klein, Marina B Klein, C. Kolan, Nadine Kronfli, F. Lamontagne, R. Lau, Todd C Lee, Nelson Lee, Rachel Lim, S. Longo, Alexandra Lostun, E. MacIntyre, Isabelle Malhamé, Kathryn Mangof, Marlee McGuinty, Sonya Mergler, Matthew Munan, S. Murthy, C. O’Neil, D. Ovakim, Jesse Papenburg, K. Parhar, S. Parvathy, Chandni Patel, S. Perez-Patrigeon, R. Pinto, Subitha Rajakumaran, Asgar Rishu, Malaika Roba-Oshin, M. Rushton, M. Saleem, M. Salvadori, K. Scherr, Kevin Schwartz, M. Semret, M. Silverman, Ameeta Singh, W. Sligl, Stephanie Smith, R. Somayaji, D. Tan, Siobhan Tobin, M. Todd, T. Tran, A. Tremblay, Jennifer L. Y. Tsang, A. Turgeon, Erik Vakil, J. Weatherald, C. Yansouni, R. Zarychanski   +82 more
semanticscholar   +1 more source

Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture models

Scientific Reports, 2021
Human coronavirus NL63 (HCoV-NL63) mainly affects young children and immunocompromised patients, causing morbidity and mortality in a subset of patients.
Yining Wang, Pengfei Li, Sajjan Rajpoot, Uzma Saqib, Peifa Yu, Yunlong Li, Yang Li, Zhongren Ma, Mirza S. Baig, Qiuwei Pan   +9 more
doaj   +1 more source

Remdesivir Use Compared With Supportive Care in Hospitalized Patients With Severe COVID-19: A Single-Center Experience. [PDF]

, 2020
BackgroundThe US Food and Drug Administration issued an Emergency Use Authorization for remdesivir use in patients with severe COVID-19.MethodsWe utilized data from 2 quaternary acute care hospitals. The outcomes of interest were the impact of remdesivir
Aridi, Jad, Aung, Su, Beckwith, Curt G, Byrd, Katrina M, Farmakiotis, Dimitrios, Flanigan, Timothy P, Garland, Joseph M, Johnson, Jennie E, Kalligeros, Markos, Larkin, Jerome, Macias Gil, Raul, Mylona, Evangelia K, Mylonakis, Eleftherios, Neill, Marguerite, O'Brien, Thomas, Pandita, Aakriti, Rybak, Natasha, Sanchez, Martha, Shehadeh, Fadi, Tashima, Karen T   +19 more
core   +1 more source

De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report

Nature Communications, 2021
SARS-CoV-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent.
S. Gandhi, J. Klein, Alexander J Robertson, Mario A. Peña-Hernández, Michelle J. Lin, Pavitra Roychoudhury, Peiwen Lu, John B. Fournier, David Ferguson, Shah A. Mohamed Bakhash, M. Catherine Muenker, Ariktha Srivathsan, Elsio A. Wunder, Nicholas Kerantzas, Wenshuai Wang, B. Lindenbach, A. Pyle, Craig B. Wilen, O. Ogbuagu, A. Greninger, A. Iwasaki, W. Schulz, A. Ko   +22 more
semanticscholar   +1 more source

Crystallographic fragment screening against SARS‐CoV‐2 nonstructural protein 1 using the F2X‐Entry Screen and a newly developed fragment library

Acta Crystallographica Section D, EarlyView.
Two crystallographic fragment screening campaigns against SARS‐CoV‐2 nonstructural protein 1 resulted in the identification of 21 new hits.Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to threaten global health. This underpins the need for novel therapeutics against this virus.
Frank Lennartz, Jan Wollenhaupt, Melanie Oelker, Paula Fröling, Uwe Mueller, Anke Deckers, Christoph Grathwol, Stefan Bräse, Nicole Jung, Manfred S. Weiss   +9 more
wiley   +1 more source

Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro

Scientific Reports, 2023
Remdesivir (GS-5734; VEKLURY) is a single diastereomer monophosphoramidate prodrug of an adenosine analog (GS-441524). Remdesivir is taken up by target cells and metabolized in multiple steps to form the active nucleoside triphosphate (GS-443902), which ...
S. Radoshitzky, Patrick Iversen, Xianghan Lu, Jing Zou, S. Kaptein, Kelly S. Stuthman, Sean A. van Tongeren, Jesse T. Steffens, R. Gong, Hoa N. Truong, Annapurna Sapre, Huiling Yang, Xiaodong Xie, Jia Jun Chia, Zhijuan Song, S. Leventhal, Josolyn Chan, A. Shornikov, Xin Zhang, D. Cowfer, Helen Yu, Travis K Warren, T. Cihlář, D. Porter, J. Neyts, P. Shi, Jay B. Wells, J. Bilello, Joy Y. Feng   +28 more
semanticscholar   +1 more source

The Effectiveness of the Use of Regdanvimab (CT-P59) in Addition to Remdesivir in Patients with Severe COVID-19: A Single Center Retrospective Study [PDF]

, 2022
Ganghee Chae, Aram Choi, Soyeoun Lim, Sooneun Park, Seungjun Lee, Youngick Ahn, Jin Hyoung Kim, Seung Won, Yangjin Jegal, Jongjoon Ahn, Eun Ji Park, Jae‐Bum Jun, Woon Jung Kwon, Taehoon Lee   +13 more
openalex   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Remdesivir for the Treatment of COVID-19: A Narrative Review

Infectious Disease and Therapy
When people get sick with COVID-19, which is caused by the SARS-CoV-2 virus, treatment with an antiviral may be needed to prevent serious illness. Remdesivir is an antiviral and was the first US Food and Drug Administration-approved treatment for COVID ...
Patrick Godwin, B. Polsonetti, Michael Caron, Thomas F. Oppelt   +3 more
semanticscholar   +1 more source