Results 41 to 50 of about 34,432 (188)
Renal Replacement Therapy, 2022 Background The mortality rate of novel coronaviral disease (COVID-19) patients undergoing dialysis is considerably higher than that of patients with normal kidney function.
Jun Ito +6 more
doaj +1 more source
Protective Effect of Remdesivir Against Pulmonary Fibrosis in Mice
Frontiers in Pharmacology, 2021 Pulmonary fibrosis is a known sequela of severe or persistent lung damage. Existing clinical, imaging and autopsy studies have shown that the lungs exhibit a pathological pulmonary fibrosis phenotype after infection with coronaviruses, including severe ...
Xiaohe Li +17 more
doaj +1 more source
DEEMD: Drug Efficacy Estimation against SARS-CoV-2 based on cell Morphology with Deep multiple instance learning [PDF]
arXiv, 2021 Drug repurposing can accelerate the identification of effective compounds for clinical use against SARS-CoV-2, with the advantage of pre-existing clinical safety data and an established supply chain. RNA viruses such as SARS-CoV-2 manipulate cellular pathways and induce reorganization of subcellular structures to support their life cycle.
arxiv
In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters
International Journal of Pharmaceutics: X, 2021 Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 levels ...
Sawittree Sahakijpijarn +7 more
doaj
The Safe Administration of Remdesivir in a Patient with Acute Kidney Injury Requiring Hemodialysis
Case Reports in Infectious Diseases, 2020 Remdesivir is a nucleoside analog prodrug with broad-spectrum antiviral activity, including against coronaviruses. This has prioritized the inclusion of remdesivir in coronavirus disease 2019 (COVID-19) clinical trials.
Vincent Peyko +2 more
doaj +1 more source
Discovering Synergistic Drug Combinations for COVID with Biological Bottleneck Models [PDF]
arXiv, 2020 Drug combinations play an important role in therapeutics due to its better efficacy and reduced toxicity. Recent approaches have applied machine learning to identify synergistic combinations for cancer, but they are not applicable to new diseases with limited combination data. Given that drug synergy is closely tied to biological targets, we propose a \
arxiv
Docking study for Protein Nsp-12 of SARS-CoV with Betalains and Alfa-Bisabolol [PDF]
arXiv, 2020 The present Health Crisis tests the response of modern science and medicine to finding treatment for a new COVID-19 disease. The presentation on the world stage of antivirals such as remdesivir, obeys to the continuous investigation of biologically active molecules with multiple theoretical, computational and experimental tools.
arxiv
European Journal of Organic Chemistry, EarlyView.The biomass pyrolysis product levoglucosenone enables the preparation of the feeding modulator 3‐deoxy‐d‐arabino‐1,4‐lactone and the diastereomer 3‐deoxy‐d‐ribono‐1,4‐lactone. The key steps involve a diastereoselective bromination using an enamine bromination‐hydrolysis strategy on the bicyclic ring‐system followed by selective nucleophilic ...
Johannes Puschnig +2 more
wiley +1 more source
Phytochemical Analysis, EarlyView.ABSTRACT Introduction The SARS‐CoV‐2 pandemic has revealed a deficiency in antiviral agents. Plants, traditionally used for respiratory infections, are valuable sources of antiviral compounds. Such a plant is the Sideritis L. taxa (mountain tea), traditionally used against cold and cough.
Ekaterina‐Michaela Tomou +5 more
wiley +1 more source
Scientific Reports, 2021 Human coronavirus NL63 (HCoV-NL63) mainly affects young children and immunocompromised patients, causing morbidity and mortality in a subset of patients.
Yining Wang +9 more
doaj +1 more source