Results 41 to 50 of about 46,545 (326)

Sophisticated sperm allocation in male fowl [PDF]

, 2003
When a female is sexually promiscuous, the ejaculates of different males compete for the fertilization of her eggs; the more sperm a male inseminates into a female, the more likely he is to fertilize her eggs.
Pizzari, T., Cornwallis, C.K., Lovlie, H., Jakobssen, S., Birkhead, T.R.   +4 more
core   +1 more source

Remling’s theorem on canonical systems

Journal of Mathematical Physics, 2016
In this paper, we extend the Remling’s theorem on canonical systems that the ω limit points of the Hamiltonian under the shift map are reflectionless on the support of the absolutely continuous part of the spectral measure of a canonical system.
openaire   +3 more sources

REML estimation for binary data in GLMMs

Journal of Multivariate Analysis, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Noh, Maengseok, Lee, Youngjo
openaire   +1 more source

Employing a Monte Carlo algorithm in Newton-type methods for restricted maximum likelihood estimation of genetic parameters.

PLoS ONE, 2013
Estimation of variance components by Monte Carlo (MC) expectation maximization (EM) restricted maximum likelihood (REML) is computationally efficient for large data sets and complex linear mixed effects models.
Kaarina Matilainen, Esa A Mäntysaari, Martin H Lidauer, Ismo Strandén, Robin Thompson   +4 more
doaj   +1 more source

Permutation inference methods for multivariate meta-analysis

, 2019
Multivariate meta-analysis is gaining prominence in evidence synthesis research because it enables simultaneous synthesis of multiple correlated outcome data, and random-effects models have generally been used for addressing between-studies ...
Furukawa, Toshi A., Nagashima, Kengo, Noma, Hisashi   +2 more
core   +1 more source

Penalized additive regression for space-time data: a Bayesian perspective [PDF]

, 2003
We propose extensions of penalized spline generalized additive models for analysing space-time regression data and study them from a Bayesian perspective.
Fahrmeir, Ludwig, Kneib, Thomas, Lang, S.   +2 more
core   +3 more sources

Stochastic Lanczos estimation of genomic variance components for linear mixed-effects models

BMC Bioinformatics, 2019
Background Linear mixed-effects models (LMM) are a leading method in conducting genome-wide association studies (GWAS) but require residual maximum likelihood (REML) estimation of variance components, which is computationally demanding. Previous work has
Richard Border, Stephen Becker
doaj   +1 more source

Optimal mapping of terrestrial gamma dose rates using geological parent material and aerogeophysical survey data [PDF]

, 2012
Regulatory authorities need ways to estimate natural terrestrial gamma radiation dose rates (nGy h−1) across the landscape accurately, to assess its potential deleterious health effects. The primary method for estimating outdoor dose rate is to use an in
Beamish, D., Rawlins, B.G., Scheib, C., Tyler, A.N.   +3 more
core   +2 more sources

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source