Results 51 to 60 of about 47,282 (299)

Binary and Ordinal Random Effects Models Including Variable Selection [PDF]

, 2010
A likelihood-based boosting approach for fitting binary and ordinal mixed models is presented. In contrast to common procedures it can be used in high-dimensional settings where a large number of potentially influential explanatory variables is available.
Groll, Andreas, Tutz, Gerhard
core   +1 more source

Explicit Effects and Effect Constraints in ReML [PDF]

Proceedings of the ACM on Programming Languages
An important aspect of building robust systems that execute on dedicated hardware and perhaps in constrained environments is to control and manage the effects performed by program code. We present ReML, a higher-order statically-typed functional language, which allows programmers to be explicit about the effects performed by program code and ...
openaire   +2 more sources

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Comparative Meta‐Analysis of Antimicrobial Peptides in Aquatic and Terrestrial Livestock Species

Animal Research and One Health, EarlyView.
A global meta‐analysis of 58 studies (926 effect sizes and 29 species across five taxa) revealed that dietary antimicrobial peptides generally improve growth performance, blood metabolites, and immune responses. The greatest benefits were observed in omnivorous livestock, such as pigs and chickens. Dose‐duration effects were evident. An optimal outcome
Lily Liu, Xu Luo, Qin Zhang, Jinhai Wang, Alan E. Wilson   +4 more
wiley   +1 more source

Stochastic Lanczos estimation of genomic variance components for linear mixed-effects models

BMC Bioinformatics, 2019
Background Linear mixed-effects models (LMM) are a leading method in conducting genome-wide association studies (GWAS) but require residual maximum likelihood (REML) estimation of variance components, which is computationally demanding. Previous work has
Richard Border, Stephen Becker
doaj   +1 more source

Genotypic selection of advanced potato clones by REML/BLUP [PDF]

Horticultura Brasileira, 2018
ABSTRACT Potato genotypes were evaluated in their performance, according to the genotype values for tuber yield traits. The experiments were carried out in Canoinhas and Pelotas, Brazil, in spring 2014. Eleven advanced clones and two commercial cultivars (Agata and Asterix) (check cultivars) were evaluated.
Silva, Giovani O, Pereira, Arione S, Azevedo, Fernanda Q, Carvalho, Agnaldo DF   +3 more
openaire   +3 more sources

Multivariate Analysis of Hematological Stress Biomarkers and Welfare Domains in Organic and Intensive Pig Farming in Italy: A Pilot Study

Animal Research and One Health, EarlyView.
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito, Talal Hassan, Antonio Marco Maisano, Stefania Bergagna, Cecilia Guasco, Barbara Miniscalco, Martina Tarantola, Elena Colombino, Claudio Caruso, Ahsan Muhammad, Silvia Mioletti, Laura Tomassone, Massimiliano Tursi, Cristina Vercelli, Giovanni Loris Alborali, Maria Teresa Capucchio   +15 more
wiley   +1 more source

Variational Bayesian Parameter Estimation Techniques for the General Linear Model

Frontiers in Neuroscience, 2017
Variational Bayes (VB), variational maximum likelihood (VML), restricted maximum likelihood (ReML), and maximum likelihood (ML) are cornerstone parametric statistical estimation techniques in the analysis of functional neuroimaging data.
Ludger Starke, Dirk Ostwald, Dirk Ostwald, Dirk Ostwald   +3 more
doaj   +1 more source

Multimodal Integration of Protein Interactomes With Genomic and Molecular Data Discovers Distinct Rheumatoid Arthritis Endotypes

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease characterized by clinical and molecular heterogeneity, notably in the presence of anti–cyclic citrullinated peptide (CCP) antibodies. Patients with CCP+ RA exhibit more severe disease progression and distinct treatment responses compared to patients with CCP− RA.
Javad Rahimikollu, Priyamvada Guha Roy, Akash Kishore, Danica Morgan Lee, Lauren A. Vanderlinden, Kiran Nazarali, Fan Zhang, Dana P. Ascherman, Daniella M. Schwartz, Larry Moreland, Jishnu Das   +10 more
wiley   +1 more source

Evaluation of Seed Yield Stability of Lentil Genotypes Based on REML/BLUP and Multi-Trait Stability Index (MTSI) [PDF]

پژوهشنامه اصلاح گیاهان زراعی
Extended Abstract Background: Lentil is a popular legume crop in the Mediterranean region, widely grown for its nutritious seeds and improving soil fertility.
Payam Pezeshkpour, Reza Amiri, Iraj Karami, Amir Mirzaei   +3 more
doaj