Results 41 to 50 of about 22,337 (298)

Fixed and Random Effects Selection by REML and Pathwise Coordinate Optimization [PDF]

open access: yesJournal of Computational and Graphical Statistics, 2013
We propose a two-stage model selection procedure for the linear mixed-effects models. The procedure consists of two steps: First, penalized restricted log-likelihood is used to select the random effects, and this is done by adopting a Newton-type algorithm.
Bingqing, Lin, Zhen, Pang, Jiming, Jiang
openaire   +2 more sources

Bivariate model for diagnostic meta-analysis, estimation method: REML.

open access: yes, 2023
Bivariate model for diagnostic meta-analysis, estimation method: REML.
Shaghayegh Khanmohammadi (14598182)   +3 more
core   +1 more source

An Efficient Algorithm for REML in Heteroscedastic Regression [PDF]

open access: yesJournal of Computational and Graphical Statistics, 2002
This article considers REML (residual or restricted maximum likelihood) estimation for heteroscedastic linear models. An explicit algorithm is given for REML scoring which yields the REML estimates together with their standard errors and likelihood values.
openaire   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

open access: yesAdvanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao   +25 more
wiley   +1 more source

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

open access: yesAdvanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba   +25 more
wiley   +1 more source

Relative difference between MC AI REML estimates and the true estimate obtained by analytical AI REML.

open access: yes, 2013
The relative difference (%) is plotted for MC AI REML estimates with 20, 100 and 1000 MC samples (green, blue and red line, respectively) along the iteration. MC EM REML with 20 MC samples is plotted as a reference (grey line).
Esa A. Mäntysaari (495420)   +4 more
core   +1 more source

Comparative Meta‐Analysis of Antimicrobial Peptides in Aquatic and Terrestrial Livestock Species

open access: yesAnimal Research and One Health, EarlyView.
A global meta‐analysis of 58 studies (926 effect sizes and 29 species across five taxa) revealed that dietary antimicrobial peptides generally improve growth performance, blood metabolites, and immune responses. The greatest benefits were observed in omnivorous livestock, such as pigs and chickens. Dose‐duration effects were evident. An optimal outcome
Lily Liu   +4 more
wiley   +1 more source

Stochastic Lanczos estimation of genomic variance components for linear mixed-effects models

open access: yesBMC Bioinformatics, 2019
Background Linear mixed-effects models (LMM) are a leading method in conducting genome-wide association studies (GWAS) but require residual maximum likelihood (REML) estimation of variance components, which is computationally demanding. Previous work has
Richard Border, Stephen Becker
doaj   +1 more source

Genotypic selection of advanced potato clones by REML/BLUP [PDF]

open access: yesHorticultura Brasileira, 2018
ABSTRACT Potato genotypes were evaluated in their performance, according to the genotype values for tuber yield traits. The experiments were carried out in Canoinhas and Pelotas, Brazil, in spring 2014. Eleven advanced clones and two commercial cultivars (Agata and Asterix) (check cultivars) were evaluated.
Silva, Giovani O   +3 more
openaire   +3 more sources

Multivariate Analysis of Hematological Stress Biomarkers and Welfare Domains in Organic and Intensive Pig Farming in Italy: A Pilot Study

open access: yesAnimal Research and One Health, EarlyView.
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito   +15 more
wiley   +1 more source

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