Oligodendrogenesis in Evolution, Development and Adulthood
Glia, Volume 73, Issue 9, Page 1770-1783, September 2025.Main Points Oligodendrocytes and myelin took shape in jawed vertebrates During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin.
Hao Hu +3 more
wiley +1 more source
A monoclonal autoantibody that promotes central nervous system remyelination in a model of multiple sclerosis is a natural autoantibody encoded by germline immunoglobulin genes. [PDF]
, 1995 David J. Miller, Moses Rodriguez
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What Does Iron Mean to an Oligodendrocyte?
Glia, Volume 73, Issue 9, Page 1784-1804, September 2025.Main Points Iron is essential for oligodendrocyte (OL) biology and myelin production, with deficiencies leading to severe neurological impairments. Understanding iron trafficking in OLs is crucial for developing treatments for dysmyelinating conditions. ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions.
Quinn W. Wade, James R. Connor
wiley +1 more source
Glia, Volume 73, Issue 9, Page 1910-1924, September 2025.Main Points Absence of DBN leads to larger spinal lesions, immune cell infiltration and attenuated astrocyte reactivity in the early phase post SCI. Absence of DBN leads to greater neurodegeneration, underscoring its importance in tissue repair.
Barbora Smejkalová +12 more
wiley +1 more source
Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons [PDF]
, 2000 Susan C. Barnett
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Microscopy Research and Technique, Volume 88, Issue 9, Page 2375-2380, September 2025.A comparison of the results of two methods, operator‐ versus machine learning (ML)‐made, for transmission electron microscopic (TEM) morphometry of mitochondria showed no statistical correlation between the two methods due to insufficient specificity of the latter.
Daniele Nosi +4 more
wiley +1 more source
Remyelinating Drugs at a Crossroad: How to Improve Clinical Efficacy and Drug Screenings
CellsAxons wrapped around the myelin sheath enable fast transmission of neuronal signals in the Central Nervous System (CNS). Unfortunately, myelin can be damaged by injury, viral infection, and inflammatory and neurodegenerative diseases.
Aland Ibrahim Ahmed Al Jaf +3 more
doaj +1 more source
Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination [PDF]
, 2000 Jeffrey L. Mason +5 more
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MedComm, Volume 6, Issue 9, September 2025.Central nervous system (CNS) diseases are driven by spatiotemporally dynamic molecular networks. Single‐cell and spatial multiomics technologies dissect cellular heterogeneity, microenvironmental remodeling, and intercellular crosstalk. Integration of transcriptomic, epigenomic, proteomic, and metabolomic layers reveals disease‐associated regulatory ...
Mingkai Xia +4 more
wiley +1 more source
PAR1 activation induces the release by Schwann cells of factors promoting cell survival and neuritogenesis [PDF]
, 2017 Protease-activated receptor 1 (PAR1) is a member of a family of four G-protein-coupled receptors which are activated by proteolytic cleavage of their N-terminal extracellular domain.
Artico, M. +7 more
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