Results 101 to 110 of about 357,421 (301)

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Vaccines in Renal Cell Carcinoma

Seminars in Oncology, 2006
Considerable progress in our understanding of the molecular and cellular events that promote growth and progression of renal cell carcinoma (RCC) has dramatically improved the prospects of significantly altering the progression and metastatic potential of renal neoplasms.
Department of Urology, University of Florida, College of Medicine, Gainesville, FL. ( host institution ), Kübler, Hubert ( author ), Vieweg, Johannes ( author )   +2 more
openaire   +3 more sources

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

, 2008
Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours.
Dietel Manfred, Fritzsche, Florian R., Weichert Wilko, Gekeler Volker, Dietel, Manfred, Fritzsche Florian R, Beckers Thomas, Kristiansen Glen, Jung, Klaus, Kristiansen, Glen, Weichert, Wilko, Jung Klaus, Scholman Katharina, Gekeler, Volker, Denkert Carsten, Röske, Annika, Röske Annika, Beckers, Thomas, Stephan, Carsten, Stephan Carsten, Scholman, Katharina, Denkert, Carsten Michael   +21 more
core   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Identification of PANoptosis-related signature reveals immune infiltration characteristics and immunotherapy responses for renal cell carcinoma

BMC Cancer
PANoptosis is a specific type of inflammatory programmed cell death (PCD) modality that can be involved in three key modes of cellular programmed cell death-pyroptosis, apoptosis and necroptosis. We analyzed PANoptosis activity in three common renal cell
Yan Xu, Jingqi Hua, Hongliang Que, Tengyue Zeng, Quan Li, Junpeng Deng, Jianjun Xie   +6 more
doaj   +1 more source

Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy

Frontiers in Cell and Developmental Biology
Renal cell carcinoma is a common type of cancer, with approximately 30% of patients potentially developing metastatic disease. Some patients with metastatic renal cell carcinoma are found in advanced stages, so the 5-year survival rate for metastatic ...
Xinwei Li, Xinwei Li, Wei Xiong, Zhiyong Xiong, Zhiyong Xiong, Xiaoping Zhang, Xiaoping Zhang, Xiaoping Zhang   +7 more
doaj   +1 more source

Overexpression of TRIM2 suppresses proliferation, migration and stemness of clear cell renal cell carcinoma cells in vitro

Di-san junyi daxue xuebao, 2019
Objective To explore the effect of tripartite motif-containing protein 2 (TRIM2) on the proliferation, migration and stemness of clear cell renal clear carcinoma.
LUO Xing, LUO Jing, LIU Xin, ZHOU Tao, SUN Bishao   +4 more
doaj   +1 more source

ROS‐Responsive Nanobubbles for Dual‐Enhanced Ultrasound and Magnetic Resonance Imaging of Tumor Oxidative Stress

Advanced Science, EarlyView.
We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung, Youngju Son, Dong Yun Lee, Youngeun Jeon, Muhammad Asaddudin, Sung‐Hong Park, Sangyong Jon   +6 more
wiley   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source